ArticleEvidence-based complementary and alternative medicine : eCAM2013
Mechanisms of electroacupuncture-induced analgesia on neuropathic pain in animal model.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The short-term efficacy of electrical pudendal nerve stimulation versus intravesical instillation for the urethral pain syndrome: a randomized clinical trial.World journal of urology · 2021Trial
- Study Protocol for Multi-Center, Open-Label, Randomized Controlled Trial for Assessing the Efficacy and Safety of Electroacupuncture for Cold Hypersensitivity in Hands and Feet.Journal of pharmacopuncture · 2025Article
- Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway.Chinese medicine · 2024Article
- Peripheral Rho-associated protein kinase activation mediates acupuncture analgesia.Integrative medicine research · 2024Article
- The analgesic and sedative effects of GV20 pharmacopuncture with low-dose hydromorphone in healthy dogs undergoing ovariohysterectomy.The Canadian veterinary journal = La revue veterinaire canadienne · 2021Article
- Needling Interventions for Sciatica: Choosing Methods Based on Neuropathic Pain Mechanisms-A Scoping Review.Journal of clinical medicine · 2021Article
- Electroacupuncture Reduces Oocyte Number and Maintains Vascular Barrier Against Ovarian Hyperstimulation Syndrome by Regulating CD200.Frontiers in cell and developmental biology · 2021Article
- Acupuncture for gouty arthritis: A PRISMA-compliant protocol for a systematic review and meta-analysis of randomized controlled trials.Medicine · 2020Article
- Purinergic signaling as a basis of acupuncture-induced analgesia.Purinergic signalling · 2020Review
- The Involvement of Descending Pain Inhibitory System in Electroacupuncture-Induced Analgesia.Frontiers in integrative neuroscience · 2019Review
- Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Electroacupuncture Relieves CCI-Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Electroacupuncture for migraine protocol for a systematic review of controlled trials.Medicine · 2018Article
- The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- The Modulatory Effect of Acupuncture on the Activity of Locus Coeruleus Neuronal Cells: A Review.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Combined Effects of Bee Venom Acupuncture and Morphine on Oxaliplatin-Induced Neuropathic Pain in Mice.Toxins · 2016Article
- Traditional Chinese medicine in patients with osteoarthritis of the knee.Journal of traditional and complementary medicine · 2015Review
- Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats.BMC complementary and alternative medicine · 2014Article
- Expression levels of the hypothalamic AMPK gene determines the responsiveness of the rats to electroacupuncture-induced analgesia.BMC complementary and alternative medicine · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain remains as one of the most difficult clinical pain syndromes to treat. Electroacupuncture (EA), involving endogenous opioids and neurotransmitters in the central nervous system (CNS), is reported to be clinically efficacious in various fields of pain. Although multiple experimental articles were conducted to assess the effect of EA-induced analgesia, no review has been published to assess the efficacy and clarify the mechanism of EA on neuropathic pain. To this aim, this study was firstly designed to evaluate the EA-induced analgesic effect on neuropathic pain and secondly to guide and help future efforts to advance the neuropathic pain treatment. For this purpose, articles referring to the analgesic effect of acupuncture on neuropathic pain and particularly the work performed in our own laboratory were analyzed. Based on the articles reviewed, the role of spinal opioidergic, adrenergic, serotonergic, cholinergic, and GABAergic receptors in the mechanism of EA-induced analgesia was studied. The results of this research demonstrate that μ and δ opioid receptors, α 2-adrenoreceptors, 5-HT1A and 5-HT3 serotonergic receptors, M1 muscarinic receptors, and GABAA and GABAB GABAergic receptors are involved in the mechanisms of EA-induced analgesia on neuropathic pain.
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Registered trials
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