ArticleDose-response : a publication of International Hormesis Society2012
Hormesis and Cellular Quality Control: A Possible Explanation for the Molecular Mechanisms that Underlie the Benefits of Mild Stress.
Article in Dose-response : a publication of International Hormesis Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Local autophagy impairment triggers brain-wide presynaptic remodeling and resilience.The EMBO journal · 2026Article
- In-Depth Analysis of Chlorophyll Fluorescence Rise Kinetics Reveals Interference Effects of a Radiofrequency Electromagnetic Field (RF-EMF) on Plant Hormetic Responses to Drought Stress.International journal of molecular sciences · 2025Article
- Existence of Quantum Pharmacology in Sartans: Evidence in Isolated Rabbit Iliac Arteries.International journal of molecular sciences · 2023Article
- Chronic Ionizing Radiation of Plants: An Evolutionary Factor from Direct Damage to Non-Target Effects.Plants (Basel, Switzerland) · 2023Review
- Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells.Cells · 2022Article
- Biostimulant Capacity of an Enzymatic Extract From Rice Bran Against Ozone-Induced Damage inFrontiers in plant science · 2021Article
- The Beneficial Role of Natural Endocrine Disruptors: Phytoestrogens in Alzheimer's Disease.Oxidative medicine and cellular longevity · 2021Review
- New approaches to cope with possible harms of low-dose environmental chemicals.Journal of epidemiology and community health · 2019Article
- Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.Nature communications · 2017Article
- Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast.Cell cycle (Georgetown, Tex.) · 2016Article
- Phytochemicals in Ischemic Stroke.Neuromolecular medicine · 2016Review
- Antifouling activity of synthetic alkylpyridinium polymers using the barnacle model.Marine drugs · 2014Article
- Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions.Dose-response : a publication of International Hormesis SocietyReview
- Metabolic Profiling of γ-Irradiated Barley Plants Identifies Reallocation of Nitrogen Metabolism and Metabolic Stress Response.Dose-response : a publication of International Hormesis SocietyArticle
- Intervention Engagement Moderates the Dose-Response Relationships in a Dietary Intervention.Dose-response : a publication of International Hormesis SocietyArticle
- Hormesis and homeopathy: The artificial twins.Journal of intercultural ethnopharmacologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to the detrimental action of severe stress conditions, the beneficial effects of mild stress, known as hormesis, is increasingly discussed and studied. A variety of applications for hormesis in risk assessment processes, anti-ageing strategies and clinical therapies have been proposed. The molecular mechanisms underlying the phenomenon of hormesis, however, are not yet fully understood. A possible mechanism that has been proposed for hormesis, the homoeostasis overshoot hypothesis, assumes that an overshoot of repair- and self-recovery mechanisms in response to mild damage can be held responsible for the beneficial effects of hormesis. The present paper proposes 'cellular quality control' as a further explanation of the molecular mechanisms underlying the benefits observed after exposure to mild stress. The most important quality control mechanisms are outlined and their known and hypothesised actions in hormesis are discussed. As an example, different aspects of protein quality control will be described in more detail, which includes the reaction of the cell upon stress-induced protein damage and -aggregation. The regulation of Heat Shock Proteins and components from the ubiquitin proteasome system as part of cellular quality control is described in relation to its beneficial role in hormesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.