ArticleTheScientificWorldJournal2013
Effects of resveratrol on methotrexate-induced testicular damage in rats.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 97 citations in OpenAlex.
- Resveratrol regulates nickel oxide-induced kidney damage by targeting the PERK/ATF-6/IRE1 and Nrf2/HO1 pathways.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Ameliorative effect of spirulina on methotrexate-induced male fertility and oxidative stress in rats.Open veterinary journal · 2025Review
- The protective effect of Ozone on the mice testicular damage induced by methotrexate.JBRA assisted reproduction · 2024Article
- Resveratrol ameliorates atrazine-induced caspase-dependent apoptosis and fibrosis in the testis of adult albino rats.Scientific reports · 2024Article
- Mechanistic aspects of ameliorative effects of Eicosapentanoic acid ethyl ester on methotrexate-evoked testiculopathy in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Effect of thymoquinone on NRF2/NF-kB/MAPK pathway in methotrexate-induced rat testis injury.Iranian journal of basic medical sciences · 2024Article
- Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats.Toxicological research · 2024Article
- Resveratrol Ameliorates Vancomycin-Induced Testicular Dysfunction in Male Rats.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Protective effects of curcumin against methotrexate-induced testicular damage in rats by suppression of the p38-MAPK and nuclear factor-kappa B pathways.Clinical and experimental reproductive medicine · 2021Article
- The modulatory impacts ofToxicology research · 2021Article
- Therapeutic Effect of Stem Cells on Male Infertility in a Rat Model: Histological, Molecular, Biochemical, and Functional Study.Stem cells international · 2021Article
- Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Molecules (Basel, Switzerland) · 2020Article
- Protective effects of apocynin on damaged testes of rats exposed to methotrexateTurkish journal of medical sciences · 2020Article
- Effect of Oat (Avena Sativa L.) Extract on Experimental Sciatic Nerve Injury in Rats.Archives of Razi Institute · 2020Article
- Protective effect of melatonin against methotrexate-induced testicular damage in the rat model: An experimental study.International journal of reproductive biomedicine · 2020Article
- Effects of Magnesium Sulfate Administration on Testicular Ischemia/Reperfusion Injury in Rats.Archives of Razi Institute · 2020Article
- Vitamin B17 Ameliorates Methotrexate-Induced Reproductive Toxicity, Oxidative Stress, and Testicular Injury in Male Rats.Oxidative medicine and cellular longevity · 2020Article
- Resveratrol Protects against Restraint Stress Effects on Stomach and Spleen in Adult Male Mice.Animals : an open access journal from MDPI · 2019Article
- Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the probable protective effects of resveratrol (RES), an antioxidant, against methotrexate- (MTX-) induced testis damage. Twenty-four male Sprague Dawley rats were randomly divided into four groups: control, RES, MTX, and MTX + RES groups. Rats were sacrificed at the end of the experiment. Plasma and tissue malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activity in tissue, testicular histopathological damage scores, and testicular and epididymal epithelial apoptotic index (AI) were evaluated. The MTX group had significantly higher plasma and tissue MDA levels and significantly lower SOD and CAT activity than those of the control group. In the MTX + RES group, plasma and tissue MDA levels decreased significantly and SOD activity rose significantly compared to the MTX group. The MTX group had significantly lower Johnsen's testicular biopsy score (JTBS) values than those of the control group. JTBS was significantly higher in the MTX + RES group than in the MTX group. AI increased in the testis and epididymis in the MTX group and significantly decreased in the MTX + RES group. Our results indicate that RES has protective effects against MTX-induced testis damage at the biochemical, histopathological, and apoptotic levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.