ArticleInternational journal of medical sciences2013
The role of serum procalcitonin levels in predicting ascitic fluid infection in hospitalized cirrhotic and non-cirrhotic patients.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Comparison of the Diagnostic Accuracies of Procalcitonin and C-Reactive Protein for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Diagnostic Accuracy of Serum Procalcitonin for Spontaneous Bacterial Peritonitis Due to End-stage Liver Disease: A Meta-analysis.Medicine · 2015Pooled it
- Significance of serum procalcitonin as biomarker for detection of bacterial peritonitis: a systematic review and meta-analysis.BMC infectious diseases · 2014Pooled it
- Performance of fecal calprotectin and serum procalcitonin for the diagnosis of spontaneous bacterial peritonitis in patients with cirrhosis: A prospective diagnostic accuracy study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- IL-1 receptor antagonist as a diagnostic biomarker for bacterial infections in acute decompensation of cirrhosis.Scientific reports · 2025Article
- Anticipating postoperative complications in hepatobiliary surgery: procalcitonine as predictive factor.Frontiers in surgery · 2025Article
- Procalcitonin and C-reactive protein in the diagnosis of spontaneous bacterial peritonitis.Translational gastroenterology and hepatology · 2022Article
- Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis.BMC emergency medicine · 2021Article
- Establishment and Validation of a Non-Invasive Diagnostic Nomogram to Identify Spontaneous Bacterial Peritonitis in Patients With Decompensated Cirrhosis.Frontiers in medicine · 2021Article
- Ascitic Interleukin 6 Is Associated with Poor Outcome and Spontaneous Bacterial Peritonitis: A Validation in Critically Ill Patients with Decompensated Cirrhosis.Journal of clinical medicine · 2020Article
- Procalcitonin and Liver Disease: A Literature Review.Journal of clinical and translational hepatology · 2019Review
- Combination of PCT, sNFI and dCHC for the diagnosis of ascites infection in cirrhotic patients.BMC infectious diseases · 2018Article
- Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis: A literature review.World journal of hepatology · 2018Review
- Serum Procalcitonin in Patients with Acute Liver Failure.Yonago acta medica · 2017Article
- A Novel Combination of C-Reactive Protein and Vascular Endothelial Growth Factor in Differential Diagnosis of Ascites.Journal of gastrointestinal cancer · 2017Article
- Ascitic Calprotectin is a Novel and Accurate Marker for Spontaneous Bacterial Peritonitis.Journal of clinical laboratory analysis · 2016Article
- Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis.Gut and liver · 2016Article
- Article
- Markers of bacterial translocation in end-stage liver disease.World journal of hepatology · 2015Review
- Blood Procalcitonin Predicts Spontaneous Bacterial Peritonitis in Patients with Cirrhosis and Ascites.Middle East journal of digestive diseases · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the role of serum procalcitonin levels in predicting ascites infection in hospitalized cirrhotic and non-cirrhotic patients.
methodsA total of 101 patients (mean age: 63.4 ± 1.3, 66.3% were males) hospitalized due to cirrhosis (n=88) or malignancy related (n=13) ascites were included in this study. Spontaneous bacterial peritonitis (SBP, 19.8%), culture-negative SBP (38.6%), bacterascites (4.9%), sterile ascites (23.8%) and malign ascites (12.9%) groups were compared in terms of procalcitonin levels in predicting ascites infection. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of procalcitonin levels and predicting outcome of procalcitonin levels was compared with C-reactive protein (CRP).
resultsCulture positivity was determined in 26.7% of overall population. Serum procalcitonin levels were determined to be significantly higher in patients with positive bacterial culture in ascitic fluid compared to patients without culture positivity (median (min-max): 4.1 (0.2-36.4) vs. 0.4 (0.04-15.8), p<0.001). Using ROC analysis, a serum procalcitonin level of <0.61 ng/mL in SBP (area under curve (AUC): 0.981, CI 95%: 0.000-1.000, p<0.001), <0.225 ng/mL in culture-negative SBP (AUC: 0.743, CI 95%: 0.619-0.867, p<0.001), <0.42 ng/mL in SBP and culture-negative SBP patients (AUC: 0.824, CI 95%: 0.732-0.916, p<0.001), and <1.12 ng/mL in bacterascites (AUC: 0.837, CI 95%: 0.000-1.000, p=0.019) were determined to accurately rule out the diagnosis of bacterial peritonitis. Predictive power of serum procalcitonin levels in SBP + culture-negative SBP group (AUCs: 0.824 vs 0.622, p=0.004, Fig 4), culture-positive SBP (AUCs: 0.981 vs 0.777, p=0.006, Fig 5) and (although less powerfull) in culture-negative SBP (AUCs: 0.743 vs 0.543, p=0.02, Fig 6) were found significantly higher than CRP.
conclusionAccording to our findings determination of serum procalcitonin levels seems to provide satisfactory diagnostic accuracy in differentiating bacterial infections in hospitalized patients with liver cirrhosis related ascites.
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