ArticleWorld journal of gastroenterology2013
High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer.
Article in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis.Disease markers · 2015Pooled it
- Study on the Diagnosis of Gastric Cancer by Magnetic Beads Extraction and Mass Spectrometry.BioMed research international · 2020Trial
- Construction and Validation of Convenient Clinicopathologic Signatures for Predicting the Prognosis of Stage I-III Gastric Cancer.Frontiers in oncology · 2022Article
- Correlation between serum carbohydrate antigen 19-9 levels and computed tomography severity score in patients with nontuberculous mycobacterial pulmonary disease.Scientific reports · 2021Article
- Clinical importance of serum CEA and CA-19-9 levels in oesophagogastric junction adenocarcinomas.Przeglad gastroenterologiczny · 2021Article
- Effectiveness of additional resection of the invasive cancer-positive proximal bile duct margin in cases of hilar cholangiocarcinoma.Hepatobiliary surgery and nutrition · 2018Article
- An Alternative Method for Screening Gastric Cancer Based on Serum Levels of CEA, CA19-9, and CA72-4.Journal of gastrointestinal cancer · 2018Article
- Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer.PloS one · 2018Article
- Early postoperative tumor marker responses provide a robust prognostic indicator for N3 stage gastric cancer.Medicine · 2017Observational
- Influence of prognostic nutritional index and tumor markers on survival in gastric cancer surgery patients.Langenbeck's archives of surgery · 2017Article
- Review
- Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer.Molecular and clinical oncology · 2016Article
- Prognostic value of neutrophil to lymphocyte ratio for gastric cancer.Annals of translational medicine · 2015Article
- Elevated serum CA 19-9 at screening tests: underlying conditions and role of abdominopelvic CT.European radiology · 2014Article
- Clinical significance of serum thymus and activation-regulated chemokine in gastric cancer: potential as a serum biomarker.Cancer science · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9 (CA 19-9) level in gastric cancer.
methodsBetween January 2005 and December 2006, 1960 patients underwent surgery for histologically confirmed gastric cancer. Of these, 163 patients had elevated serum levels of CA 19-9 preoperatively, and 1628 patients had normal serum levels of CA 19-9 preoperatively. For this study, 325 patients were selected from the group of 1628 patients by age, sex, and cancer stage to serve as controls. Statistically significant differences in survival rates were calculated using the log-rank test. A P value less than 0.05 was considered statistically significant and was determined using SAS software.
resultsThe baseline characteristics showed some differences between the two groups with regard to histology. Overall survival (OS) in the elevated and non-elevated group was 37.90 and 68.67 mo, respectively (P < 0.001). N stage (P = 0.001) was a significant predictor of disease-free survival by multivariate analysis. Also, N stage (P < 0.001), and the presence of peritoneal metastasis (P < 0.001) remained independent factors in predicting OS by multivariate analysis. Additionally, preoperative serum CA 19-9 levels were significantly associated with OS in univariate (P = 0.009) and multivariate (P = 0.021) analyses.
conclusionSerum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.
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