ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2012
Histological changes in the heart and the proximal aorta in experimental diabetic rats fed with Piper sarmentsoum.
Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil fromHeliyon · 2023Article
- Melatonin ameliorates serobiochemical alterations and restores the cardio-nephro diabetic vascular and cellular alterations in streptozotocin-induced diabetic rats.Frontiers in veterinary science · 2023Article
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- Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes.Investigational new drugs · 2020Article
- Methylmercury exposure develops atherosclerotic risk factors in the aorta and programmed cell death in the cerebellum: ameliorative action of Celastrus paniculatus ethanolic extract in male Wistar rats.Environmental science and pollution research international · 2018Article
- The Chinese Herb Yi-Qi-Huo-Xue Protects Cardiomyocyte Function in Diabetic Cardiomyopathy.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction.Molecular medicine reports · 2017Article
- Anti-Atherosclerotic Potential of Aqueous Extract ofJournal of clinical and diagnostic research : JCDR · 2017Article
- PRE-CLINICAL EVALUATION OF EXTRACTS AND ESSENTIAL OILS FROM BETEL-LIKE SCENTAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Effect of polysaccharide from Bacillus subtilis sp. on cardiovascular diseases and atherogenic indices in diabetic rats.BMC complementary and alternative medicine · 2016Article
- Effect of Momordica charantia fruit extract on vascular complication in type 1 diabetic rats.EXCLI journal · 2015Article
- Protective effect of Momordica charantia fruit extract on hyperglycaemia-induced cardiac fibrosis.Oxidative medicine and cellular longevity · 2014Article
- Effect of Piper sarmentosum Extract on the Cardiovascular System of Diabetic Sprague-Dawley Rats: Electron Microscopic Study.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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4 authors.
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Abstract
Cardiovascular complications are one of the major causes of death in diabetes mellitus. Piper sarmentosum (P.s) is an herb that possesses antihyperglycaemic effects. The main aim of the study was to observe the histological changes in the heart and the proximal aorta of streptozotocin-induced diabetic rats following P.s administration. Twenty-four male Sprague-Dawley rats (n=24) were equally randomized into four groups: control group supplemented with normal saline (C); control group supplemented with P.s (CTx) ; diabetic group supplemented with normal saline (D) and, diabetic group supplemented with P.s (DTx). Diabetes was induced by STZ (50mg/kg body weight) intramuscularly. P.s extract (0.125g/kg) was administered orally for 28 days, following four weeks of STZ induction. The cardiac and aortic tissues were collected and processed under different stains: Haematoxylin and Eosin (H & E), Verhoeff-Van Gieson (VVG), Masson's Trichome (MT) and Periodic Acid- Schiff (PAS). There were abnormal cardiomyocytes nuclei, disarray of myofibres and increase in connective tissue deposits in cardiac tissues of the diabetic untreated group. The thickness of tunica media and ratio of tunica intima to media were found to be significantly increased in the aorta of diabetic untreated group (P < 0.05) compared to the control group. There were degenerative changes in the proximal aorta in diabetic untreated groups. All the histological damages of cardiac and aortic tissues were found to be lesser in the diabetic treated groups. Supplementation with P.s extract prevented the oxidative damage arising from diabetes mellitus, and reduced its complications.
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23983373PMC3746658What OpenQuestion holds
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