ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2013
Temporal stability of serum concentrations of cytokines and soluble receptors measured across two years in low-risk HIV-seronegative men.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A systematic review and meta-analysis of the stability of peripheral immune markers in healthy adults.Brain, behavior, and immunity · 2023Pooled it
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- Depression treatment response to ketamine: sex-specific role of interleukin-8, but not other inflammatory markers.Translational psychiatry · 2021Trial
- Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis.Cytokine · 2018Trial
- Multiplex assay reliability and long-term intra-individual variation of serologic inflammatory biomarkers.Cytokine · 2017Trial
- Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study.Molecular autism · 2017Trial
- Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin.Brain, behavior, and immunity · 2015Trial
- Oncostatin M as a Complementary Non-Invasive Marker of Endoscopic and Histological Disease Activity in Ulcerative Colitis.International journal of molecular sciences · 2026Article
- Serum Oncostatin M in Ulcerative Colitis Patients and Its Relation to Disease Activity.International journal of molecular sciences · 2025Article
- Systemic Neuroprotection by Chlorogenic Acid: Antioxidant and Anti-inflammatory Evaluation in Early Neurodegeneration Induced by 3-Nitropropionic Acid in Mice.Neurochemical research · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
- Soluble TNFR1 has greater reproducibility than IL-6 for the assessment of chronic inflammation in older adults: the case for a new inflammatory marker in aging.GeroScience · 2024Article
- Maternal cytokine profiles in second and early third trimester are not predictive of preterm birth.PloS one · 2024Article
- AMC-070: Lenalidomide Is Safe and Effective in HIV-Associated Kaposi Sarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Changes of immune-related factors in the blood of schizophrenia and bipolar disorder patients receiving monotherapy.Translational psychiatry · 2022Article
- Longitudinal trajectory of response to electroconvulsive therapy associated with transient immune response & white matter alteration post-stimulation.Translational psychiatry · 2022Article
- Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking.Cancers · 2021Article
- Interbatch Reliability of Blood-Based Cytokine and Chemokine Measurements in Community-Dwelling Older Adults: A Cross-Sectional Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Association between pre-diagnostic circulating adipokines and colorectal cancer and adenoma in the CLUE II cohort.Cancer causes & control : CCC · 2021Article
- Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression.Journal of psychiatric research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundProspective cohort studies often quantify serum immune biomarkers at a single time point to determine risk of cancer and other chronic diseases that develop years later. Estimates of the within-person temporal stability of serum markers partly assess the utility of single biomarker measurements and may have important implications for the design of prospective studies of chronic disease risk.
methodsUsing archived sera collected from 200 HIV-seronegative men at three visits spaced over approximately 2 years, concentrations of 14 biomarkers (ApoA1, sCD14, sgp130, sIL-6R, sIL-2Rα, sTNFR2, BAFF/BLyS, CXCL13, IFN-γ, interleukin [IL]-1β, IL-6, IL-8, IL-10, and TNF-α) were measured in a single laboratory. Age- and ethnicity-adjusted intraclass correlation coefficients (ICC) were calculated for each biomarker, and mixed linear regression models were used to examine the influence of age, ethnicity, season, and study site on biomarker concentrations.
resultsAcross all three study visits, most biomarkers had ICC values indicating fair to excellent within-person stability. ApoA1 (ICC = 0.88) and TNF-α (ICC = 0.87) showed the greatest stability; the ICC for IL-8 (ICC = 0.33) was remarkably less stable. The ICCs were similar when calculated between pairs of consecutive visits. The covariables did not influence biomarker levels or their temporal stability. All biomarkers showed moderate to strong pairwise correlations across visits.
conclusionsSerum concentrations of most evaluated immune biomarkers displayed acceptable to excellent within-person temporal reliability over a 2-year period. Further investigation may be required to clarify the stability of IL-8. IMPACT: These findings lend support to using these serologic immune biomarkers in prospective studies investigating associations with chronic diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.