ArticleObesity (Silver Spring, Md.)2014
Metabolic inflexibility during submaximal aerobic exercise is associated with glucose intolerance in obese older adults.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- Exercise-Induced Improvements in Insulin Sensitivity Are Not Attenuated by a Family History of Type 2 Diabetes.Frontiers in endocrinology · 2020Trial
- Two Weeks of Interval Training Enhances Fat Oxidation during Exercise in Obese Adults with Prediabetes.Journal of sports science & medicine · 2019Trial
- Assessing metabolic flexibility in adults under physiological conditions: Effects of dietary fat and exercise in whole-room calorimetry.Physiological reports · 2026Article
- Neuromuscular electrical stimulation enhances glycemic control and carbohydrate utilization in sedentary, predominantly Hispanic overweight or obese individuals with hyperglycemia.European journal of applied physiology · 2026Article
- Lifestyle Interventions to Tackle Cardiovascular Risk in Thyroid Hormone Signaling Disorders.Nutrients · 2025Review
- Exercise Testing for Metabolic Flexibility: Time for Protocol Standardization.Sports medicine - open · 2025Article
- Independent influence of type 2 diabetes on reduced cardiopulmonary fitness in patients after percutaneous coronary intervention: a cross-sectional study.Scientific reports · 2025Article
- A pilot study evaluating differences in muscle tissue saturation and blood flow between older adults with and without sarcopenia.Frontiers in endocrinology · 2025Article
- Article
- Metabolic dysfunction and the development of physical frailty: an aging war of attrition.GeroScience · 2024Review
- Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review.Nutrients · 2023Review
- Metabolic Flexibility and Inflexibility: Pathology Underlying Metabolism Dysfunction.Journal of clinical medicine · 2023Article
- Review
- Impact of Ageing on Female Metabolic Flexibility: A Cross-Sectional Pilot Study in over-60 Active Women.Sports medicine - open · 2022Article
- Differential fuel utilization in liver transplant recipients and its relationship with non-alcoholic fatty liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults.Journal of cachexia, sarcopenia and muscle · 2022Article
- Impact of Sarcopenia on the Severity of the Liver Damage in Patients With Non-alcoholic Fatty Liver Disease.Frontiers in nutrition · 2021Review
- Metabolic Response to Submaximal and Maximal Exercise in People with Severe Obesity, Prediabetes, and Diabetes.Obesity facts · 2021Article
- Harnessing Muscle-Liver Crosstalk to Treat Nonalcoholic Steatohepatitis.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePeople with type 2 diabetes have reduced cardiorespiratory fitness and metabolic impairments that are linked to obesity and often occur prior to the development of type 2 diabetes. We hypothesized that obese, older adults with impaired glucose tolerance (IGT) have lower ability to shift from fat to carbohydrate oxidation when transitioning from rest to submaximal exercise than normal glucose tolerant (NGT) controls. DESIGN AND
methodsGlucose tolerance, body composition, and substrate oxidation (measured by RER:respiratory exchange ratio) during submaximal exercise (50% and 60% VO₂max ) and insulin infusion (3-hour hyperinsulinemic-euglycemic clamp) were assessed in 23 sedentary, overweight-obese, older men and women.
resultsObese subjects with NGT (n = 13) and IGT (n = 10) had similar resting RER, but during submaximal exercise those with IGT had a lower RER and less transition to carbohydrate oxidation than the NGT group (P < 0.05). The IGT group also oxidized less carbohydrate during insulin infusion than NGT (P < 0.05). RER at each exercise intensity independently correlated with 120-minute postprandial glucose (r = -0.54 to -0.58, P < 0.05), but not with body composition, VO₂max , or RER during insulin infusion.
conclusionsObese, older adults have metabolic inflexibility during exercise that is associated with the degree of glucose intolerance independent of age and body composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.