ArticleThe Journal of comparative neurology2014
Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks.Molecular psychiatry · 2025Review
- Local and long-range input balance: A framework for investigating frontal cognitive circuit maturation in health and disease.Science advances · 2024Review
- Reorganization of dopamine circuitry in the anterior corpus callosum between early adolescence and adulthood in the mouse.The European journal of neuroscience · 2024Article
- Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood.Psychopharmacology · 2022Article
- Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice.Behavioural brain research · 2022Article
- Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner.Frontiers in behavioral neuroscience · 2022Article
- Areas of Convergence and Divergence in Adolescent Social Isolation and Binge Drinking: A Review.Frontiers in behavioral neuroscience · 2022Review
- Impact of Early Life Stress on Reward Circuit Function and Regulation.Frontiers in psychiatry · 2021Review
- Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development.Frontiers in neural circuits · 2021Review
- Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Decreased environmental complexity during development impairs habituation of reinforcer effectiveness of sensory stimuli.Behavioural brain research · 2018Article
- Abundant collateralization of temporal lobe projections to the accumbens, bed nucleus of stria terminalis, central amygdala and lateral septum.Brain structure & function · 2017Article
- Functional evidence for a direct excitatory projection from the lateral habenula to the ventral tegmental area in the rat.Journal of neurophysiology · 2016Article
- Effects of early life stress on amygdala and striatal development.Developmental cognitive neuroscience · 2016Review
- Alcohol-induced alterations in dopamine modulation of prefrontal activity.Alcohol (Fayetteville, N.Y.) · 2015Review
- Sources of input to the rostromedial tegmental nucleus, ventral tegmental area, and lateral habenula compared: A study in rat.The Journal of comparative neurology · 2015Article
- Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?Physiology & behavior · 2015Review
- Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a DCC-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The mesocorticolimbic dopamine system has long attracted the interest of researchers concerned with the unique gamut of behavioral and mental health vulnerabilities associated with adolescence. Accordingly, the development of the mesocorticolimbic system has been studied extensively, but almost exclusively with regard to dopaminergic output, particularly in the nucleus accumbens and medial prefrontal cortex. To the contrary, the ontogeny of inputs to the ventral tegmental area (VTA), the source of mesocorticolimbic dopamine, has been neglected. This is not a trivial oversight, as the activity of VTA neurons, which reflects their capacity to transmit information about salient events, is sensitively modulated by inputs. Here, we assessed the development of VTA afferent connections using the β subunit of cholera toxin (Ctβ) as a retrograde axonal tracer in adolescent (postnatal day 39) and early adult (8-9-week-old) rats. After intra-VTA injections of Ctβ, adolescent and early adult animals exhibited qualitatively similar distributions of retrogradely labeled neurons in the sense that VTA-projecting neurons were present at all of the same rostrocaudal levels in all of the same structures in both age groups. However, quantitation of retrogradely labeled neurons revealed that adolescent brains, compared with early adult brains, had significantly fewer VTA-projecting neurons preferentially within an interconnected network of cortical and striatopallidal forebrain structures. These findings provide a novel perspective on the development of the mesocorticolimbic dopamine system and may have important implications for age-dependent specificity in the function of this system, particularly with regard to adolescent impulsivity and mental health vulnerabilities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.