ReviewJournal of anesthesia2014
Cerebral dysfunction after coronary artery bypass surgery.
Review in Journal of anesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02267538 (Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Which aortic clamp strategy is better to reduce postoperative stroke and death: Single center report and a meta-analysis.Medicine · 2018Pooled it
- Effects of the nontourniquet combined with controlled hypotension technique on pain and long-term prognosis in elderly patients after total knee arthroplasty: a randomized controlled study.Journal of anesthesia · 2019Trial
- [Effects of cerebral oxygen changes during coronary bypass surgery on postoperative cognitive dysfunction in elderly patients: a pilot study].Brazilian journal of anesthesiology (Elsevier)Trial
- Biomarkers of perioperative neurocognitive disorders after cardiac surgery: from mechanistic insights to clinical translation.Frontiers in neuroscience · 2026Review
- Effect of Cerebrolysin on Cognitive Function and Delirium in Coronary Artery Bypass Graft Patients.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Risk Score Elaboration for Stroke in Cardiac Surgery.Brazilian journal of cardiovascular surgery · 2021Article
- Perioperative Psychological Interventions in Heart Surgery–Opportunities and Clinical Benefit.Deutsches Arzteblatt international · 2021Review
- The relationship between aortic calcification on chest radiograph and neurocognitive impairment after coronary artery bypass grafting.Turk gogus kalp damar cerrahisi dergisi · 2021Article
- Assessment of risk factors for postoperative cognitive dysfunction after coronary artery bypass surgery: a single-center retrospective cohort study.Bioscience reports · 2021Article
- Relative cerebral hyperperfusion during cardiopulmonary bypass is associated with risk for postoperative delirium: a cross-sectional cohort study.BMC anesthesiology · 2019Article
- Efficacy of Neurocognitive Rehabilitation After Coronary Artery Bypass Graft Surgery in Improving Quality of Life: An Interventional Trial.Frontiers in psychology · 2019Article
- Cognitive function in patients with coronary artery disease: A literature review.The Journal of international medical research · 2018Review
- Perioperative stroke - Prediction, Prevention, and Protection.Indian journal of anaesthesia · 2018Review
- The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment.Frontiers in psychiatry · 2018Review
- Cardiopulmonary Bypass in a Mouse Model: A Novel Approach.Journal of visualized experiments : JoVE · 2017Article
- The role of Perioperative Surgical Home on health and longevity in society: importance of the surgical prehabilitation program.Journal of anesthesia · 2017Article
- A technique for continuous bedside monitoring of global cerebral energy state.Intensive care medicine experimental · 2016Article
- Management of cognition as reported in Japanese historical documents and modern anesthesiology research papers.Journal of anesthesia · 2016Article
- Effects of Heart Bypass Surgery on Plasma Aβ40 and Aβ42 Levels in Infants and Young Children.Medicine · 2016Article
- Exposure to Ketamine Anesthesia Affects Rat Impulsive Behavior.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral dysfunction after cardiac surgery remains a devastating complication and is growing in importance with our aging populations. Neurological complications following cardiac surgery can be classified broadly as stroke, encephalopathy (including delirium), or postoperative cognitive dysfunction (POCD). These etiologies are caused primary by cerebral emboli, hypoperfusion, or inflammation that has largely been attributed to the use of cardiopulmonary bypass. Preventative operative strategies, such as off-pump coronary artery bypass grafting (CABG), can potentially reduce the incidence of postoperative neurological complications by avoiding manipulation of the ascending aorta. Although off-pump CABG is associated with reduced risk of stroke, there are no convincing differences in POCD between off-pump and on-pump CABG. Recently, the focus of postoperative neurological research has shifted from managing cardiopulmonary bypass to patient-related factors. Identifying changes in brains of aged individuals undergoing cardiac surgery may improve strategies for preventing cerebral dysfunction. Advanced age is associated with more undiagnosed cerebrovascular disease and is a major risk factor for stroke and POCD following cardiac surgery. Preoperative cerebrovascular evaluation and adaptation of surgical strategies will provide preventative approaches for cerebral dysfunction after CABG. This review focuses on recent findings of the relationship between perioperative stress and underlying fragility of the brain in cardiac surgical patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.