Evidence map›Paper›PMID 23982524›Full record

GuidelineNature reviews. Clinical oncology2013

The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma.

Howard L Kaufman, John M Kirkwood, F Stephen Hodi, Sanjiv Agarwala, Thomas Amatruda, Steven D Bines, Joseph I Clark, Brendan Curti, Marc S Ernstoff, Thomas Gajewski and 20 more

Open access · hybridAbstract readConsensus StatementPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Nature reviews. Clinical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.

  1. Pooled it
  2. The cost-effectiveness of nivolumab monotherapy for the treatment of advanced melanoma patients in England.The European journal of health economics : HEPAC : health economics in prevention and care · 2018
    Trial
  3. A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.Annals of oncology : official journal of the European Society for Medical Oncology · 2015
    Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Malignant melanoma of gastrointestinal tract onAmerican journal of nuclear medicine and molecular imaging · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 4 countries.

Howard L KaufmanRush University Cancer Center, 1725 West Harrison Street, Chicago, IL 60612, USA.
John M Kirkwood
F Stephen Hodi
Sanjiv Agarwala
Thomas Amatruda
Steven D Bines
Joseph I Clark
Brendan Curti
Marc S Ernstoff
Thomas Gajewski
Rene Gonzalez
Laura Jane Hyde
David Lawson
Michael Lotze
Jose Lutzky
Kim Margolin
David F McDermott
Donald Morton
Anna Pavlick
Jon M Richards
William Sharfman
Vernon K Sondak
Jeffrey Sosman
Susan Steel
Ahmad Tarhini
John A Thompson
Jill Titze
Walter Urba
Richard White
Michael B Atkins
Rush University · USUniversity of Pittsburgh · USProvidence College · USUniversity of Washington · USAdvocate Lutheran General Hospital · USCancer Institute (WIA) · INCarolinas Medical Center · USDana-Farber Cancer Institute · USDartmouth College · USGeorgetown University · USHarvard University Press · USJohns Hopkins University · USLoyola University Medical Center · USMinnesota Oncology · USMoffitt Cancer Center · USMount Sinai Medical Center · USNew York University · USSierra Club · USSKiN Health · CASt. Luke's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy is associated with durable clinical benefit in patients with melanoma. The goal of this article is to provide evidence-based consensus recommendations for the use of immunotherapy in the clinical management of patients with high-risk and advanced-stage melanoma in the USA. To achieve this goal, the Society for Immunotherapy of Cancer sponsored a panel of melanoma experts--including physicians, nurses, and patient advocates--to develop a consensus for the clinical application of tumour immunotherapy for patients with melanoma. The Institute of Medicine clinical practice guidelines were used as a basis for this consensus development. A systematic literature search was performed for high-impact studies in English between 1992 and 2012 and was supplemented as appropriate by the panel. This consensus report focuses on issues related to patient selection, toxicity management, clinical end points and sequencing or combination of therapy. The literature review and consensus panel voting and discussion were used to generate recommendations for the use of immunotherapy in patients with melanoma, and to assess and rate the strength of the supporting evidence. From the peer-reviewed literature the consensus panel identified a role for interferon-α2b, pegylated-interferon-α2b, interleukin-2 (IL-2) and ipilimumab in the clinical management of melanoma. Expert recommendations for how to incorporate these agents into the therapeutic approach to melanoma are provided in this consensus statement. Tumour immunotherapy is a useful therapeutic strategy in the management of patients with melanoma and evidence-based consensus recommendations for clinical integration are provided and will be updated as warranted.

Indexed as

ImmunotherapyCutaneous Malignant MelanomaDisease ManagementEvidence-Based MedicineHumansMedical OncologyMelanomaSkin NeoplasmsSocieties, MedicalUnited States

Identifiers

PMID23982524
OpenAlexW2018652183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.