ArticleMedical science monitor basic research2013
Plumbagin induces the apoptosis of human tongue carcinoma cells through the mitochondria-mediated pathway.
Article in Medical science monitor basic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
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- Rhizoma Paridis Saponins Induces Cell Cycle Arrest and Apoptosis in Non-Small Cell Lung Carcinoma A549 Cells.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry.Medical science monitor basic research · 2015Article
- Plumbagin induces growth inhibition of human glioma cells by downregulating the expression and activity of FOXM1.Journal of neuro-oncology · 2015Article
- Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells.Drug design, development and therapy · 2015Article
- A simple method to assess in vivo proliferation in lung vasculature with EdU: the case of MMC-induced PVOD in rat.Analytical cellular pathology (Amsterdam) · 2015Article
- Effects of a simulated CO2 pneumoperitoneum environment on the proliferation, apoptosis, and metastasis of cervical cancer cells in vitro.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Toxic effects of levofloxacin on rat annulus fibrosus cells: an in-vitro study.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlumbagin, a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been proven to possess anti-tumor activity both in vitro and in vivo. However, its anti-tumor properties for human tongue carcinoma have not been reported. This study aimed to investigate the inhibitory effect and the underlying mechanism of plumbagin on the growth of human tongue carcinoma cells. MATERIAL AND
methodsCell proliferation ability was detected by EdU incorporation assay and colony formation assay. Cell-cycle distribution was determined by flow cytometric analysis using propidium iodide (PI) staining. Cellular apoptosis was then evaluated by flow cytometry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Western blotting was applied to assay the expression of Bax and Bcl-2.
resultsPlumbagin inhibited the growth and proliferation of Tca8113 cells in vitro in a concentration- and time-dependent manner. The cell cycles of plumbagin-treated Tca8113 cells were arrested at the G2/M phase. Cells treated with plumbagin presented the characteristic morphological changes of apoptosis. The ratio of Bax/Bcl-2 was raised by plumbagin in a concentration-dependent manner.
conclusionsThese results indicate that plumbagin induces the apoptosis of Tca8113 cells through mitochondria-mediated pathway.
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