Evidence map›Paper›PMID 23982425›Full record

Observational studyInternational journal of colorectal disease2014

Is complete mesocolic excision with central vascular ligation safe and effective in the surgical treatment of right-sided colon cancers? A prospective study.

Gennaro Galizia, Eva Lieto, Ferdinando De Vita, Francesca Ferraraccio, Anna Zamboli, Andrea Mabilia, Annamaria Auricchio, Paolo Castellano, Vincenzo Napolitano, Michele Orditura

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04871399 (Complete Mesocolic Excision With Central Vascular Ligation in Comparison With Conventional Surgery for the Right Colon Cancer), which is not on this map. Cited by 59 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04871399 narecruitingnot on this mapstarted 2020, after this paper: background citation

Complete Mesocolic Excision With Central Vascular Ligation in Comparison With Conventional Surgery for the Right Colon Cancer: An Italian Randomized Trial

TypeinterventionalSponsorUniversity of Turin, ItalyRan2020 to 2027Enrolled416ConditionsColon CancerArmsConventional Right hemicolectomy (Non-CME), Right hemicolectomy with CME+CVL
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
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  10. Review
  11. Article
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  14. Quality assessment of surgery for colorectal cancer: Where do we stand?World journal of gastrointestinal surgery · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Transmesocolic approach in laparoscopic complete mesocolic excision for right sided colon cancers.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gennaro GaliziaDivision of Surgical Oncology, F. Magrassi-A. Lanzara" Department of Clinical and Experimental Medicine and Surgery, School of Medicine, Second University of Naples, c/o II Policlinico, Edificio 17 Via Pansini, 5, 80131, Naples, Italy, gennaro.galizia@unina2.it.
Eva Lieto
Ferdinando De Vita
Francesca Ferraraccio
Anna Zamboli
Andrea Mabilia
Annamaria Auricchio
Paolo Castellano
Vincenzo Napolitano
Michele Orditura

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeComplete mesocolic excision (CME) with central vascular ligation (CVL) has been proposed for treatment of colon cancers based on the same principles as total mesorectal excision. Impressive outcomes have been reported, however, direct comparisons with the classic procedure are lacking.

methodsForty-five consecutive patients operated on in the last 5 years with CME and CVL right hemicolectomy entered the study. Fifty-eight right-sided colon cancer patients operated in the previous 5 years with classic approach constituted the control group. Intra- and postoperative course assessed the safety of the procedure. Primary end-points for oncological adequacy were recurrence and survival rate.

resultsAll operations were successful with no increase in postoperative complications (p = 0.85). Number of harvested nodes and length of vascular ligation were shown to be significantly better in the CME group (p < 0.01). A higher number of tumor deposits were harvested thus allowing chemotherapy in newly upstaged patients. Locoregional recurrences were never experienced in CME patients (p = 0.03). The risk of cancer-related death was reduced by over one half in all CME patients, and even by three quarters in node-positive tumors. The classic operation was significantly associated with poor outcome (p < 0.01).

conclusionThis study shows that CME with CVL is a safe and effective surgical approach for right colon cancer, thus confirming the previously reported oncological adequacy. The procedure was shown to significantly decrease local recurrences and to improve the survival rate, particularly in node-positive patients. Urgent diffusion of this technique is warranted.

Indexed as

AdultAgedAged, 80 and overColonic NeoplasmsEndpoint DeterminationFemaleHumansLigationMaleMesocolonMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalProspective StudiesSurvival RateTreatment Outcome

Identifiers

PMID23982425

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.