Evidence map›Paper›PMID 23982330›Full record

ReviewScientific reports2013

Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma.

Si-Qi Qiu, Xiao-Long Wei, Wen-He Huang, Ming-Yao Wu, Yun-Sheng Qin, Yang-Kang Li, Guo-Jun Zhang

Abstract readCase ReportsReview
In one paragraph

Review in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Si-Qi Qiu1] The Breast Center, Cancer Hospital of Shantou University Medical College, Guangdong, China [2].
Xiao-Long Wei
Wen-He Huang
Ming-Yao Wu
Yun-Sheng Qin
Yang-Kang Li
Guo-Jun Zhang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential diagnosis, and to identify prognostic factors. All tumors lacked epithelial markers but expressed mesenchymal markers, suggesting a mesenchymal origin. Of the five cases expressing Ki-67, two of three patients with axillary lymph node involvement died between 6-8 months, and two died at 17 and 26 months after diagnosis. The two remaining cases, with low Ki-67 expression, had no recurrent or metastatic disease at 145 months after diagnosis. Previous studies have shown that surgery is the primary treatment of choice, but no clear benefit from adjuvant chemotherapy was observed. We demonstrate that axillary lymph node involvement and high expression of Ki-67 are associated with poorer prognosis. A literature review indicates surgery remains the first choice for MFH, but benefits from adjuvant chemotherapy remain unclear.

Indexed as

Biomarkers, TumorBreast NeoplasmsHistiocytoma, Malignant FibrousKi-67 AntigenAdultAgedFemaleHumansMaleMiddle AgedReproducibility of ResultsSensitivity and SpecificityTreatment OutcomeYoung AdultBiomarkers, TumorKi-67 Antigen

Identifiers

PMID23982330
PMCPMC3755283

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.