ArticleCurrent microbiology2014
Morin inhibits sortase A and subsequent biofilm formation in Streptococcus mutans.
Article in Current microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Natural 2-phenyl chroman flavonoids against Streptococcus mutans: prospects of herbal remedies for dental caries.Journal of materials science. Materials in medicine · 2026Review
- Maple polyphenols inhibit sortase and drastically reduceMicrobiology spectrum · 2025Article
- Berberine chloride hydrate impairs Streptococcus mutans biofilm formation via inhibiting sortase A activity.NPJ biofilms and microbiomes · 2025Article
- Inhibitory effect of plant flavonoid cyanidin on oral microbial biofilm.Microbiology spectrum · 2025Article
- Inhibitory Effects onPlants (Basel, Switzerland) · 2024Article
- Maple compounds prevent biofilm formation inFrontiers in microbiology · 2024Article
- Berberine disrupts staphylococcal proton motive force to cause potent anti-staphylococcal effectsBiofilm · 2023Article
- Article
- Inhibition of biofilm formation and virulence factors of cariogenic oral pathogenJournal of oral microbiology · 2023Article
- Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases-A Review.Molecules (Basel, Switzerland) · 2022Review
- Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening.The Journal of antibiotics · 2022Article
- Inhibition ofJournal of oral microbiology · 2022Article
- Novel antimicrobial agents targeting theFrontiers in cellular and infection microbiology · 2022Review
- Recent Update on Applications of Quaternary Ammonium Silane as an Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry.Frontiers in microbiology · 2022Review
- Identification of Novel Antistaphylococcal Hit Compounds Targeting Sortase A.Molecules (Basel, Switzerland) · 2021Article
- Targeting Bacterial Sortases in Search of Anti-Virulence Therapies with Low Risk of Resistance Development.Pharmaceuticals (Basel, Switzerland) · 2021Review
- In Silico Selection and In Vitro Evaluation of New Molecules That Inhibit the Adhesion ofInternational journal of molecular sciences · 2020Article
- TargetingMedChemComm · 2019Review
- Astilbin Inhibits the Activity of Sortase A fromMolecules (Basel, Switzerland) · 2019Article
- Quercetin impairs Streptococcus pneumoniae biofilm formation by inhibiting sortase A activity.Journal of cellular and molecular medicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans (S. mutans) is the main etiological agent of dental caries, and adheres to the tooth surface through the sortase A (SrtA)-mediated cell wall-anchored protein Pac. Inhibition of SrtA activity results in a marked reduction in the adhesion potential of S. mutans, and the frequency of dental caries. Morin is a natural plant extract that was previously reported to inhibit Staphylococcus aureus SrtA activity. Here, we demonstrate that morin has an inhibitory effect against S. mutans UA159 SrtA, with an IC50 of 27.2 ± 2.6 μM. Western blotting demonstrated that 30 μM morin induced the partial release of the Pac protein into the supernatant. The biofilm mass of S. mutans was reduced in the presence of 30 μM morin, which was not caused by a decrease in S. mutans viability. These results indicate that morin might be important as a new agent to prevent caries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.