ArticleScientific reports2013
Long-term biopersistence of tangled oxidized carbon nanotubes inside and outside macrophages in rat subcutaneous tissue.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Recent advances in electroactive biomaterials and electrical stimulation for skeletal muscle regeneration: materials, strategies, and mechanistic insights.Materials today. Bio · 2026Review
- Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Carbon Nanotubes: Smart Drug/Gene Delivery Carriers.International journal of nanomedicine · 2021Review
- Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Article
- Clearance of single-wall carbon nanotubes from the mouse lung: a quantitative evaluation.Nanoscale advances · 2020Article
- Biotransformation of Pristine and Oxidized Carbon Nanotubes by the White Rot FungusNanomaterials (Basel, Switzerland) · 2019Article
- Time-dependent degradation of carbon nanotubes correlates with decreased reactive oxygen species generation in macrophages.International journal of nanomedicine · 2019Article
- Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells.International journal of nanomedicine · 2018Article
- Facile synthesis of silicon nitride nanowires with flexible mechanical properties and with diameters controlled by flow rate.Scientific reports · 2017Article
- Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide Nanoparticles.ACS applied materials & interfaces · 2016Article
- Interaction of single and multi wall carbon nanotubes with the biological systems: tau protein and PC12 cells as targets.Scientific reports · 2016Article
- High resolution and dynamic imaging of biopersistence and bioreactivity of extra and intracellular MWNTs exposed to microglial cells.Biomaterials · 2015Article
- Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells.International journal of nanomedicine · 2014Article
- Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide.International journal of nanomedicine · 2014Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of their mechanical strength, chemical stability, and low molecular weight, carbon nanotubes (CNTs) are attractive biological implant materials. Biomaterials are typically implanted into subcutaneous tissue or bone; however, the long-term biopersistence of CNTs in these tissues is unknown. Here, tangled oxidized multi-walled CNTs (t-ox-MWCNTs) were implanted into rat subcutaneous tissues and structural changes in the t-ox-MWCNTs located inside and outside of macrophages were studied for 2 years post-implantation. The majority of the large agglomerates were present in the intercellular space, maintained a layered structure, and did not undergo degradation. By contrast, small agglomerates were found inside macrophages, where they were gradually degraded in lysosomes. None of the rats displayed symptoms of cancer or severe inflammatory reactions such as necrosis. These results indicate that t-ox-MWCNTs have high biopersistence and do not evoke adverse events in rat subcutaneous tissue in vivo, demonstrating their potential utility as implantable biomaterials.
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