ArticleMolecular imaging2013
In vivo demonstration of cancer molecular imaging with ultrasound radiation force and buried-ligand microbubbles.
Article in Molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Acoustically driven micro/nanobubbles: from fundamental mechanisms to biomedical applications.Microsystems & nanoengineering · 2026Review
- Frequency-Selective Microbubble TargetingACS applied bio materials · 2025Article
- Methods for Rapid Characterization of Tunable Microbubble Formulations.Bioengineering (Basel, Switzerland) · 2024Article
- Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.Pharmaceutics · 2023Review
- Monodispersity Increases Adhesion Efficiency and Specificity for Ultrasound-Targeted Microbubbles.ACS biomaterials science & engineering · 2023Article
- Nanosized Contrast Agents in Ultrasound Molecular Imaging.Frontiers in bioengineering and biotechnology · 2021Review
- Microbubble Radiation Force-Induced Translation in Plane-Wave Versus Focused Transmission Modes.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
- Development of Antibody-Modified Nanobubbles Using Fc-Region-Binding Polypeptides for Ultrasound Imaging.Pharmaceutics · 2019Article
- Production of acoustic radiation force using ultrasound: methods and applications.Expert review of medical devices · 2018Review
- Construction of ultrasonic nanobubbles carrying CAIX polypeptides to target carcinoma cells derived from various organs.Journal of nanobiotechnology · 2017Article
- Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.Investigative radiology · 2015Article
- Two-bubble acoustic tweezing cytometry for biomechanical probing and stimulation of cells.Biophysical journal · 2015Article
- A Targeting Microbubble for Ultrasound Molecular Imaging.PloS one · 2015Article
- In vivo thrombolysis with targeted microbubbles loading tissue plasminogen activator in a rabbit femoral artery thrombus model.Journal of thrombosis and thrombolysis · 2014Article
- State-of-the-art materials for ultrasound-triggered drug delivery.Advanced drug delivery reviews · 2014Review
- Targeting of microbubbles: contrast agents for ultrasound molecular imaging.Journal of drug targetingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In designing targeted contrast agent materials for imaging, the need to present a targeting ligand for recognition and binding by the target is counterbalanced by the need to minimize interactions with plasma components and to avoid recognition by the immune system. We have previously reported on a microbubble imaging probe for ultrasound molecular imaging that uses a buried-ligand surface architecture to minimize unwanted interactions and immunogenicity. Here we examine for the first time the utility of this approach for in vivo molecular imaging. In accordance with previous results, we showed a threefold increase in circulation persistence through the tumor of a fibrosarcoma model in comparison with controls. The buried-ligand microbubbles were then activated for targeted adhesion through the application of noninvasive ultrasound radiation forces applied specifically to the tumor region. Using a clinical ultrasound scanner, microbubbles were activated, imaged, and silenced. The results showed visually conspicuous images of tumor neovasculature and a twofold increase in ultrasound radiation force enhancement of acoustic contrast intensity for buried-ligand microbubbles, whereas no such increase was found for exposed-ligand microbubbles. We therefore conclude that the use of acoustically active buried-ligand microbubbles for ultrasound molecular imaging bridges the demand for low immunogenicity with the necessity of maintaining targeting efficacy and imaging conspicuity in vivo.
Indexed as
Identifiers
23981781PMC4494687W2181308680What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.