ArticleThe Journal of physiology2013
Activity-dependent downregulation of D-type K+ channel subunit Kv1.2 in rat hippocampal CA3 pyramidal neurons.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
- Anti-Kv1.2 Immunoprecipitation Identifies shared mGluR1-Associated Signalosome Complex proteins and PKC-Mediated Regulation of Kv1.2 in the Cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Input-specific bidirectional regulation of hippocampal CA3 pyramidal cell excitability.The Journal of physiology · 2025Article
- Roles of KCNA2 in Neurological Diseases: from Physiology to Pathology.Molecular neurobiology · 2024Review
- Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation.Molecular brain · 2023Article
- Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.PLoS computational biology · 2021Article
- Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation.Experimental & molecular medicine · 2021Article
- The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases.Frontiers in synaptic neuroscience · 2021Review
- Topographic heterogeneity of intrinsic excitability in mouse hippocampal CA3 pyramidal neurons.Journal of neurophysiology · 2020Article
- Early-Life Neglect Alters Emotional and Cognitive Behavior in a Sex-Dependent Manner and Reduces Glutamatergic Neuronal Excitability in the Prefrontal Cortex.Frontiers in psychiatry · 2020Article
- Lactate induces synapse-specific potentiation on CA3 pyramidal cells of rat hippocampus.PloS one · 2020Article
- Intracellular ZnThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Fast and flexible sequence induction in spiking neural networks via rapid excitability changes.eLife · 2019Article
- Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus.Marine drugs · 2018Article
- TNF-α increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia.Scientific reports · 2018Article
- The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning.Experimental neurobiology · 2018Review
- Characterizing Concentration-Dependent Neural Dynamics of 4-Aminopyridine-Induced Epileptiform Activity.Epilepsy journal · 2018Article
- Long-Term Depression of Intrinsic Excitability Accompanied by Synaptic Depression in Cerebellar Purkinje Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding.Nature reviews. Neuroscience · 2017Review
- The role of axonal Kv1 channels in CA3 pyramidal cell excitability.Scientific reports · 2017Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The intrinsic excitability of neurons plays a critical role in the encoding of memory at Hebbian synapses and in the coupling of synaptic inputs to spike generation. It has not been studied whether somatic firing at a physiologically relevant frequency can induce intrinsic plasticity in hippocampal CA3 pyramidal cells (CA3-PCs). Here, we show that a conditioning train of 20 action potentials (APs) at 10 Hz causes a persistent reduction in the input conductance and an acceleration of the AP onset time in CA3-PCs, but not in CA1-PCs. Induction of such long-term potentiation of intrinsic excitability (LTP-IE) was accompanied by a reduction in the D-type K(+) current, and was abolished by the inhibition of endocytosis or protein tyrosine kinase (PTK). Consistently, the CA3-PCs from Kv1.2 knock-out mice displayed no LTP-IE with the same conditioning. Furthermore, the induction of LTP-IE depended on the back-propagating APs (bAPs) and intact distal apical dendrites. These results indicate that LTP-IE is mediated by the internalization of Kv1.2 channels from the distal regions of apical dendrites, which is triggered by bAP-induced dendritic Ca(2+) signalling and the consequent activation of PTK.
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