Evidence map›Paper›PMID 23981250›Full record

ArticleInfluenza and other respiratory viruses2013

Seasonal influenza vaccine effectiveness among children, 2010-2012.

Chuanxi Fu, Qing He, Zhaotian Li, Jianxiong Xu, Yongqian Li, Jianyun Lu, Kuibiao Li, Qiongying Yang, Zhiqiang Dong, Xiangyi Liu and 6 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Seasonal influenza vaccine effectiveness among children, 2010-2012.Influenza and other respiratory viruses · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chuanxi FuGuangzhou Center for Disease Control and Prevention, Guangzhou, China.
Qing He
Zhaotian Li
Jianxiong Xu
Yongqian Li
Jianyun Lu
Kuibiao Li
Qiongying Yang
Zhiqiang Dong
Xiangyi Liu
Sijun Wen
Wensui Hu
Danfeng Zhang
Jiayun Lv
Wei Zhu
Ming Wang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe annual differences in the seasonal influenza vaccine and the circulating strains make it necessary to assess influenza vaccine effectiveness (VE) yearly. We assessed the effectiveness of the trivalent inactivated influenza vaccine for the 2010-2011 and 2011-2012 influenza seasons among children in Guangzhou, China.

methodsWe conducted a 1:2 matched case-control study based on date of birth (±7 days), gender, and area of residence. The influenza cases from surveillance sites in Guangzhou were laboratory-confirmed during the 2010-2012 seasons. The controls were randomly selected from children aged 6-59 months in the Children's Expanded Programmed Immunization Administrative Computerized System. The influenza vaccination information for both cases and controls was retrieved from this system.

resultsWe analyzed the vaccination information for 1255 influenza cases and 2510 matched controls in 2 influenza seasons in Guangzhou, China. We found that the VE for vaccination during the 2010-2011 and 2011-2012 seasons of virus circulation was 73·2% (95% confidence interval (CI), 52·2-85·0%) and 52·9% (95% CI, 42·1-61·7%), respectively. The VE decreased from 68·9% (95% CI, 57·5-77·2%) in the period between January and March to 48·4% (95% CI, 33·8-59·7%) in the period between April and June.

conclusionsThis post-licensing study of VE found moderate protection against influenza for vaccinated children aged 6-59 months. Although the influenza vaccine strains for the 2010-2011 and the 2011-2012 seasons were the same, our study indicated that annual vaccination is recommended even for those who received the vaccine during the previous season.

Indexed as

Case-Control StudiesChild, PreschoolChinaFemaleHumansInfantInfluenza, HumanInfluenza VaccinesMaleVaccines, InactivatedInfluenza VaccinesVaccines, InactivatedCase-control studieschildrenChinaseasonal influenzavaccine

Identifiers

PMID23981250
PMCPMC4634265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.