ArticleAstrobiology2013
Effect of SPE-like proton or photon radiation on the kinetics of mouse peripheral blood cells and radiation biological effectiveness determinations.
Article in Astrobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- An Experimental Model of Proton-Beam-Induced Radiation Dermatitis In Vivo.International journal of molecular sciences · 2023Article
- Accumulation of CytochromeInternational journal of molecular sciences · 2022Article
- Radiologic technologists in Saudi Arabia: Does long-term exposure to radiation increase the risk of hematological disorders?Saudi medical journal · 2021Article
- Platelets in Wound Healing: What Happens in Space?Frontiers in bioengineering and biotechnology · 2021Review
- Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice.iScience · 2020Article
- Distinct vascular genomic response of proton and gamma radiation-A pilot investigation.PloS one · 2019Article
- Limitations in predicting the space radiation health risk for exploration astronauts.NPJ microgravity · 2018Review
- Effects of a granulocyte colony stimulating factor, Neulasta, in mini pigs exposed to total body proton irradiation.Life sciences in space research · 2015Article
- Article
- Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit.Life (Basel, Switzerland) · 2014Review
- Effect of Gender on the Radiation Sensitivity of Murine Blood Cells.Gravitational and space research : publication of the American Society for Gravitational and Space Research · 2014Article
- Effects of Solar Particle Event-Like Proton Radiation and/or Simulated Microgravity on Circulating Mouse Blood Cells.Gravitational and space research : publication of the American Society for Gravitational and Space Research · 2014Article
- Orally Administered Fructose Increases the Numbers of Peripheral Lymphocytes Reduced by Exposure of Mice to Gamma or SPE-like Proton Radiation.Life sciences in space research · 2014Article
- Biological Effects of Space Radiation and Development of Effective Countermeasures.Life sciences in space research · 2014Article
- Ionizing radiation selectively reduces skin regulatory T cells and alters immune function.PloS one · 2014Article
- Hindlimb suspension and SPE-like radiation impairs clearance of bacterial infections.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exploration missions outside low-Earth orbit are being planned; therefore, it is critical to understand the risk astronauts would be exposed to in the space environment, especially during extravehicular activities (EVAs). Reductions in white blood cell (WBC) numbers can occur as a result of exposure to solar particle event (SPE) radiation. The aim of the present study was to determine the duration of the effects on blood cell numbers from exposure to a single whole-body dose of SPE-like proton radiation or photon radiation as well as to determine the radiation biological effectiveness (RBE) values at those times when radiation exposure causes blood cell numbers to experience the most critical effects when using mice as a model. Our results indicate that both types of radiation cause significant reductions in the numbers of all blood cell types at different times post-irradiation. The RBE values were not significantly different from 1.0. These results indicate that the risk estimations for astronauts from exposure of mice to SPE-like proton radiation are comparable to those previously made for doses of standard reference radiations, suggesting that countermeasures should be developed for the decreases in blood cell counts observed following the exposure of mice to SPE radiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.