ArticleMolecular plant pathology2014
Overexpression of cotton GhMKK4 enhances disease susceptibility and affects abscisic acid, gibberellin and hydrogen peroxide signalling in transgenic Nicotiana benthamiana.
Article in Molecular plant pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 37 citations in OpenAlex.
- A TaMYB2-TaMAP3K17 module enhances drought tolerance by promoting reactive oxygen species scavenging in wheat.aBIOTECH · 2026Article
- Transcription factor MdWRKY50 correlates with spur-type formation in apple by modulating endogenous gibberellin biosynthesis.BMC plant biology · 2025Article
- Monoterpenoids from Artemisia austriaca essential oil disrupt hormone-mediated reserve mobilization to suppress Avena fatua seed germination.Pest management science · 2025Article
- Genome-Wide Identification of MAPKK and MAPKKK Gene Family Members and Transcriptional Profiling Analysis during Bud Dormancy in Pear (Plants (Basel, Switzerland) · 2022Article
- Genome-Wide Identification and Analysis ofInternational journal of molecular sciences · 2021Article
- The Histone Marks Signature in Exonic and Intronic Regions Is Relevant in Early Response of Tomato Genes toPlants (Basel, Switzerland) · 2020Article
- The cotton MAPK kinase GhMPK20 negatively regulates resistance to Fusarium oxysporum by mediating the MKK4-MPK20-WRKY40 cascade.Molecular plant pathology · 2018Article
- Identification on mitogen-activated protein kinase signaling cascades by integrating protein interaction with transcriptional profiling analysis in cotton.Scientific reports · 2018Article
- Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling.Frontiers in plant science · 2018Review
- Genome-wide classification, evolutionary analysis and gene expression patterns of the kinome in Gossypium.PloS one · 2018Article
- ghr-miR5272a-mediated regulation of GhMKK6 gene transcription contributes to the immune response in cotton.Journal of experimental botany · 2017Article
- GhMAP3K65, a Cotton Raf-Like MAP3K Gene, Enhances Susceptibility to Pathogen Infection and Heat Stress by Negatively Modulating Growth and Development in Transgenic Nicotiana benthamiana.International journal of molecular sciences · 2017Article
- Drought coping strategies in cotton: increased crop per drop.Plant biotechnology journal · 2017Review
- Article
- Integration analysis of MKK and MAPK family members highlights potential MAPK signaling modules in cotton.Scientific reports · 2016Article
- Analyzing serial cDNA libraries revealed reactive oxygen species and gibberellins signaling pathways in the salt response of Upland cotton (Gossypium hirsutum L.).Plant cell reports · 2015Article
- Overexpression of GhWRKY27a reduces tolerance to drought stress and resistance to Rhizoctonia solani infection in transgenic Nicotiana benthamiana.Frontiers in physiology · 2015Article
- Tomato SlMKK2 and SlMKK4 contribute to disease resistance against Botrytis cinerea.BMC plant biology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinase (MAPK) cascades are involved in plant development, stress responses and hormonal signal transduction. MAPK kinases (MAPKKs), as the key nodes in these cascades, link MAPKs and MAPKK kinases (MAPKKKs). In this study, GhMKK4, a novel group C MAPKK gene from cotton (Gossypium hirsutum), was isolated and identified. Its expression can be induced by various stresses and signalling molecules. The overexpression of GhMKK4 in Nicotiana benthamiana enhanced its susceptibility to bacterial and fungal pathogens, but had no significant effects on salt or drought tolerance. Notably, the overexpressing plants showed increased sensitivity to abscisic acid (ABA) and gibberellin A3 (GA3), and ABA and gibberellin (GA) signalling were affected on infection with Ralstonia solanacearum bacteria. Furthermore, the overexpressing plants showed more reactive oxygen species (ROS) accumulation and stronger inhibition of catalase (CAT), a ROS-scavenging enzyme, than control plants after salicylic acid (SA) treatment. Interestingly, two genes encoding ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC), the key enzymes in polyamine synthesis, exhibited reduced R. solanacearum-induced expression in overexpressing plants. These findings broaden our knowledge about the functions of MAPKKs in diverse signalling pathways and the negative regulation of disease resistance in the cotton crop.
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