ArticleThe Journal of general physiology2013
Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.
Article in The Journal of general physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
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- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: II. Assessing cochlear nerve health status with the interphase gap effect and the phase locking value.Hearing research · 2026Article
- The Interphase Gap Effect in Cochlear Implant Users: Biological Basis, Parameter Selection, Analytical Methods, and Quantitative Scales.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Engineering of functional auditory neurons from human induced pluripotent stem cells.Military Medical Research · 2026Article
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Structural basis for hyperpolarization-dependent opening of human HCN1 channel.Nature communications · 2024Article
- Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel.bioRxiv : the preprint server for biology · 2023Article
- Amplification of input differences by dynamic heterogeneity in the spiral ganglion.Journal of neurophysiology · 2022Article
- Intrinsic properties of avian interaural level difference sound localizing neurons.Brain research · 2021Article
- HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.Journal of neuroscience research · 2021Article
- Hearing and Vocalizations in the Naked Mole-Rat.Advances in experimental medicine and biology · 2021Article
- Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.Molecular neurobiology · 2020Article
- Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers.Journal of neurotrauma · 2020Article
- Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals aFrontiers in molecular neuroscience · 2020Article
- Increasing the expression level of ChR2 enhances the optogenetic excitability of cochlear neurons.Journal of neurophysiology · 2019Article
- Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice.Frontiers in aging neuroscience · 2018Article
- Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity.Frontiers in molecular neuroscience · 2018Article
- Cellular Computations Underlying Detection of Gaps in Sounds and Lateralizing Sound Sources.Trends in neurosciences · 2017Review
- Deleting the HCN1 Subunit of Hyperpolarization-Activated Ion Channels in Mice Impairs Acoustic Startle Reflexes, Gap Detection, and Spatial Localization.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Predictions of the Contribution of HCN Half-Maximal Activation Potential Heterogeneity to Variability in Intrinsic Adaptation of Spiral Ganglion Neurons.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
The hyperpolarization-activated current, Ih, is carried by members of the Hcn channel family and contributes to resting potential and firing properties in excitable cells of various systems, including the auditory system. Ih has been identified in spiral ganglion neurons (SGNs); however, its molecular correlates and their functional contributions have not been well characterized. To investigate the molecular composition of the channels that carry Ih in SGNs, we examined Hcn mRNA harvested from spiral ganglia of neonatal and adult mice using quantitative RT-PCR. The data indicate expression of Hcn1, Hcn2, and Hcn4 subunits in SGNs, with Hcn1 being the most highly expressed at both stages. To investigate the functional contributions of HCN subunits, we used the whole-cell, tight-seal technique to record from wild-type SGNs and those deficient in Hcn1, Hcn2, or both. We found that HCN1 is the most prominent subunit contributing to Ih in SGNs. Deletion of Hcn1 resulted in reduced conductance (Gh), slower activation kinetics (τfast), and hyperpolarized half-activation (V1/2) potentials. We demonstrate that Ih contributes to SGN function with depolarized resting potentials, depolarized sag and rebound potentials, accelerated rebound spikes after hyperpolarization, and minimized jitter in spike latency for small depolarizing stimuli. Auditory brainstem responses of Hcn1-deficient mice showed longer latencies, suggesting that HCN1-mediated Ih is critical for synchronized spike timing in SGNs. Together, our data indicate that Ih contributes to SGN membrane properties and plays a role in temporal aspects of signal transmission between the cochlea and the brain, which are critical for normal auditory function.
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