ArticleProceedings of the National Academy of Sciences of the United States of America2013
Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Review
- Machine Learning-Based Clustering of Layer-Resolved fMRI Activation and Functional Connectivity Within the Primary Somatosensory Cortex in Nonhuman Primates.Human brain mapping · 2025Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.medRxiv : the preprint server for health sciences · 2024Article
- In vivo neuropil density from anatomical MRI and machine learning.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Contrasting dose-dependent effects of acute intravenous methamphetamine on lateral hypothalamic extracellular glucose dynamics in male and female rats.Journal of neurophysiology · 2022Article
- Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations.PloS one · 2022Article
- Resting cerebral oxygen metabolism exhibits archetypal network features.Human brain mapping · 2021Article
- Regional variation in neurovascular coupling and why we still lack a Rosetta Stone.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Validating Linear Systems Analysis for Laminar fMRI: Temporal Additivity for Stimulus Duration Manipulations.Brain topography · 2021Article
- Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations.Scientific reports · 2020Article
- Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models.NeuroImage · 2019Review
- Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRNeuroImage · 2019Review
- Laminar fMRI: What can the time domain tell us?NeuroImage · 2019Review
- Functional connectivity with cortical depth assessed by resting state fMRI of subregions of S1 in squirrel monkeys.Human brain mapping · 2019Article
- Optical imaging and modulation of neurovascular responses.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Layer-specific neurophysiologic, hemodynamic, and metabolic measurements are needed to interpret high-resolution functional magnetic resonance imaging (fMRI) data in the cerebral cortex. We examined how neurovascular and neurometabolic couplings vary vertically in the rat's somatosensory cortex. During sensory stimulation we measured dynamic layer-specific responses of local field potential (LFP) and multiunit activity (MUA) as well as blood oxygenation level-dependent (BOLD) signal and cerebral blood volume (CBV) and blood flow (CBF), which in turn were used to calculate changes in oxidative metabolism (CMR(O2)) with calibrated fMRI. Both BOLD signal and CBV decreased from superficial to deep laminae, but these responses were not well correlated with either layer-specific LFP or MUA. However, CBF changes were quite stable across laminae, similar to LFP. However, changes in CMR(O2) and MUA varied across cortex in a correlated manner and both were reduced in superficial lamina. These results lay the framework for quantitative neuroimaging across cortical laminae with calibrated fMRI methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.