ArticleProceedings of the National Academy of Sciences of the United States of America2013
Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- A Live Cell Protein Complementation Assay for ORFeome-Wide Probing of Human HOX Interactomes.Cells · 2023Article
- Agonist antibody discovery: Experimental, computational, and rational engineering approaches.Drug discovery today · 2022Review
- Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Biasing human epidermal growth factor receptor 4 (HER4) tyrosine kinase signaling with antibodies: Induction of cell death by antibody-dependent HER4 intracellular domain trafficking.Cancer science · 2020Article
- An agonist antibody prefers relapsed AML for induction of cells that kill each other.Scientific reports · 2019Article
- Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Combinatorial antibody libraries: new advances, new immunological insights.Nature reviews. Immunology · 2016Review
- An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Activating pleiotropic receptors to kill cancer cells.Cell cycle (Georgetown, Tex.) · 2016Article
- Agonist antibody that induces human malignant cells to kill one another.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Selection strategies for anticancer antibody discovery: searching off the beaten path.Trends in biotechnology · 2015Review
- Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics.Molecules (Basel, Switzerland) · 2015Review
- In-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulation.PloS one · 2014Article
- Directing stem cell differentiation with antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When combinatorial antibody libraries are rendered infectious for eukaryotic cells, the integrated antibody genotype and cellular phenotype become permanently linked and each cell becomes a selection system unto itself. These systems should be ideal for the identification of proteins and pathways that regulate differentiation so long as selection systems can be devised. Here we use a selection system based on the ability of secreted antibodies to alter the morphology of colonies expressing them when grown in soft agar. Importantly, this approach is different from all previous studies in that it used a pure discovery format where unbiased libraries that were not preselected against any known protein were used as probes. As such, the strategy is analogous to classical forward genetic approaches except that it operates directly at the protein level. This approach led to the identification of integrin-binding agonist antibodies that efficiently converted human stem cells to dendritic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.