ArticleProceedings of the National Academy of Sciences of the United States of America2013
Mouse model implicates GNB3 duplication in a childhood obesity syndrome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- CSN-CRL Complexes: New Regulators of Adipogenesis.Biomolecules · 2025Review
- Bitter taste receptors: Genes, evolution and health.Evolution, medicine, and public health · 2021Review
- Sodium valproate combined with levetiracetam in pediatric epilepsy and its influence on NSE, IL-6, hs-CRP and electroencephalogram improvement.Experimental and therapeutic medicine · 2020Article
- Review
- Genetic variants conferring susceptibility to gastroschisis: a phenomenon restricted to the interaction with the environment?Pediatric surgery international · 2018Review
- Chromosomal microarray analysis in the genetic evaluation of 279 patients with syndromic obesity.Molecular cytogenetics · 2018Article
- WD40 repeat domain proteins: a novel target class?Nature reviews. Drug discovery · 2017Review
- SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of CaScientific reports · 2017Article
- GNB3 overexpression causes obesity and metabolic syndrome.PloS one · 2017Article
- Association between GNB3 c.825C > T polymorphism and the risk of overweight and obesity: A meta-analysis.Meta gene · 2016Article
- Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness.American journal of human genetics · 2016Article
- Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.International journal of obesity (2005) · 2016Article
- Influence of G-protein β-Polypeptide 3 C825T Polymorphism on Antihypertensive Response to Telmisartan and Amlodipine in Chinese Patients.Chinese medical journal · 2016Article
- Human Structural Variation: Mechanisms of Chromosome Rearrangements.Trends in genetics : TIG · 2015Review
- Replacing SNAP-25b with SNAP-25a expression results in metabolic disease.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Two New Cases of 1p21.3 Deletions and an Unbalanced Translocation t(8;12) among Individuals with Syndromic Obesity.Molecular syndromology · 2015Article
- Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.Cellular signalling · 2014Article
- Investigation of selected genomic deletions and duplications in a cohort of 338 patients presenting with syndromic obesity by multiplex ligation-dependent probe amplification using synthetic probes.Molecular cytogenetics · 2014Article
- New insight into adiponectin role in obesity and obesity-related diseases.BioMed research international · 2014Review
- The genetics of microdeletion and microduplication syndromes: an update.Annual review of genomics and human genetics · 2014Review
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Authors and funding
23 authors at 6 institutions in 2 countries.
Funding
Abstract
Obesity is a highly heritable condition and a risk factor for other diseases, including type 2 diabetes, cardiovascular disease, hypertension, and cancer. Recently, genomic copy number variation (CNV) has been implicated in cases of early onset obesity that may be comorbid with intellectual disability. Here, we describe a recurrent CNV that causes a syndrome associated with intellectual disability, seizures, macrocephaly, and obesity. This unbalanced chromosome translocation leads to duplication of over 100 genes on chromosome 12, including the obesity candidate gene G protein β3 (GNB3). We generated a transgenic mouse model that carries an extra copy of GNB3, weighs significantly more than its wild-type littermates, and has excess intraabdominal fat accumulation. GNB3 is highly expressed in the brain, consistent with G-protein signaling involved in satiety and/or metabolism. These functional data connect GNB3 duplication and overexpression to elevated body mass index and provide evidence for a genetic syndrome caused by a recurrent CNV.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.