ArticleG3 (Bethesda, Md.)2013
Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Base editing for precision therapeutics.Cell genomics · 2026Review
- Directed mutagenesis in fruit crops.3 Biotech · 2025Review
- Synthetic gene circuits in plants: recent advances and challenges.Quantitative plant biology · 2025Review
- Physiological and Molecular Mechanisms of Lepidopteran Insects: Genomic Insights and Applications of Genome Editing for Future Research.International journal of molecular sciences · 2024Review
- Compendium of Plant-Specific CRISPR Vectors and Their Technical Advantages.Life (Basel, Switzerland) · 2021Review
- Progresses, Challenges, and Prospects of Genome Editing in Soybean (Frontiers in plant science · 2020Review
- Can Designer Indels Be Tailored by Gene Editing?: Can Indels Be Customized?BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Article
- Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster.PLoS genetics · 2019Article
- Profile of Dana Carroll.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Insights into maize genome editing via CRISPR/Cas9.Physiology and molecular biology of plants : an international journal of functional plant biology · 2018Review
- Comparative analysis of chimeric ZFP-, TALE- and Cas9-piggyBac transposases for integration into a single locus in human cells.Nucleic acids research · 2017Article
- Biasing genome-editing events toward precise length deletions with an RNA-guided TevCas9 dual nuclease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Spatial organization of heterologous metabolic system in vivo based on TALE.Scientific reports · 2016Article
- Stable gene replacement in barley by targeted double-strand break induction.Journal of experimental botany · 2016Article
- Origins of Programmable Nucleases for Genome Engineering.Journal of molecular biology · 2016Review
- The Development of TALE Nucleases for Biotechnology.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti.Cell reports · 2015Article
- Damaging the Integrated HIV Proviral DNA with TALENs.PloS one · 2015Article
- Making designer mutants in model organisms.Development (Cambridge, England) · 2014Review
- A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering in Drosophila.G3 (Bethesda, Md.) · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Zinc-finger nucleases have proven to be successful as reagents for targeted genome manipulation in Drosophila melanogaster and many other organisms. Their utility has been limited, however, by the significant failure rate of new designs, reflecting the complexity of DNA recognition by zinc fingers. Transcription activator-like effector (TALE) DNA-binding domains depend on a simple, one-module-to-one-base-pair recognition code, and they have been very productively incorporated into nucleases (TALENs) for genome engineering. In this report we describe the design of TALENs for a number of different genes in Drosophila, and we explore several parameters of TALEN design. The rate of success with TALENs was substantially greater than for zinc-finger nucleases , and the frequency of mutagenesis was comparable. Knockout mutations were isolated in several genes in which such alleles were not previously available. TALENs are an effective tool for targeted genome manipulation in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.