ArticleLasers in medical science2014
Raman spectroscopy detection of molecular changes associated with two experimental models of osteoarthritis in rats.
Article in Lasers in medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Clinical and Animal Studies of Waist and Knee Scraping Therapy for Knee Osteoarthritis.Combinatorial chemistry & high throughput screening · 2024Trial
- Classification of osteoarthritic and healthy cartilage using deep learning with Raman spectra.Scientific reports · 2024Article
- Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications.Bone research · 2024Review
- Prognostic potential and pathological validation of a diagnostic application using Raman spectroscopy in the characterization of degenerative changes in the cartilage of the humeral head.Journal of biomedical optics · 2022Article
- Raman Spectroscopy in Skeletal Tissue Disorders and Tissue Engineering: Present and Prospective.Tissue engineering. Part B, Reviews · 2022Review
- Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls.Analytical methods : advancing methods and applications · 2022Article
- Raman needle arthroscopy for in vivo molecular assessment of cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Vibrational Spectroscopy in Assessment of Early Osteoarthritis-A Narrative Review.International journal of molecular sciences · 2021Review
- Comparison of concentrated fresh mononuclear cells and cultured mesenchymal stem cells from bone marrow for bone regeneration.Stem cells translational medicine · 2021Article
- Optical Biomarkers for the Diagnosis of Osteoarthritis through Raman Spectroscopy: Radiological and Biochemical Validation Using Ex Vivo Human Cartilage Samples.Diagnostics (Basel, Switzerland) · 2021Article
- Allogeneic adipose-derived stem cell transplantation on knee osteoarthritis rats and its effect on MMP-13 and DDR2.Experimental and therapeutic medicine · 2019Article
- Raman spectroscopy applications in rheumatology.Lasers in medical science · 2019Review
- Biochemical changes in injured sciatic nerve of rats after low-level laser therapy (660 nm and 808 nm) evaluated by Raman spectroscopy.Lasers in medical science · 2019Article
- Raman Spectroscopy: Guiding Light for the Extracellular Matrix.Frontiers in bioengineering and biotechnology · 2019Review
- Shortwave-infrared Raman spectroscopic classification of water fractions in articular cartilage ex vivo.Journal of biomedical optics · 2018Article
- Effect of Posterior Cruciate Ligament Rupture on Biomechanical and Histological Features of Lateral Femoral Condyle.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Analysis of experimental tendinitis in rats treated with laser and platelet-rich plasma therapies by Raman spectroscopy and histometry.Lasers in medical science · 2016Article
- Comparison of the Chemical Composition of Subchondral Trabecular Bone of Medial Femoral Condyle between with Advanced Osteoarthritis and without Osteoarthritis.Journal of bone metabolism · 2015Article
- Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra.Journal of biophotonics · 2015Article
- Effect of low-level laser therapy in an experimental model of osteoarthritis in rats evaluated through Raman spectroscopy.Photomedicine and laser surgery · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to evaluate the feasibility of applying Raman spectroscopy in probing the molecular changes in terms of collagen deposition and tissue remodeling associated with two well-established experimental models of osteoarthritis (OA) in knee of rats. In order to evaluate alterations in the articular surface area, the menisci-covered tibial region was assessed into three groups as follows: control (joint preserved) and two models of experimental knee OA: collagenase-induced model (n = 8) and treadmill exercise-induced model (n = 8). Each group was examined for molecular changes using spectral parameters related to cartilage, subchondral bone, and bone tissues. A significant increase of Raman ratios related to mineralization and tissue remodeling was found (p < 0.05), suggesting that both models were successful for inducing OA in rats. The significantly lower phenylalanine content and higher crystallinity in the treadmill exercise-induced model of OA than collagenase-induced model of OA (p < 0.05) indicated that the OA pathogenesis was model-dependent. Thus, this work suggests that the Raman spectroscopy technique has potential for the diagnosis and detection of cartilage damage and monitoring of subchondral bone and bone in OA pathogenesis at the molecular level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.