ArticleAntimicrobial agents and chemotherapy2013
A novel fexA variant from a canine Staphylococcus pseudintermedius isolate that does not confer florfenicol resistance.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Comparative Phenotypic and PCR-Based Methicillin Resistance Characterization of Clinical CanineAntibiotics (Basel, Switzerland) · 2026Article
- Genomic Analyses of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Genome characteristics of themSystems · 2023Article
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- Antimicrobial and Biocide Resistance among Feline and CanineAntibiotics (Basel, Switzerland) · 2022Article
- Article
- Resurgence of Chloramphenicol Resistance in Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- S. pseudintermedius and S. aureus lineages with transmission ability circulate as causative agents of infections in pets for years.BMC veterinary research · 2021Article
- Mutations in the Phenicol Exporter GeneFrontiers in microbiology · 2021Article
- Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China.The Journal of international medical research · 2018Article
- Antimicrobial Resistance among Staphylococci of Animal Origin.Microbiology spectrum · 2018Review
- Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes.PloS one · 2018Article
- Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.Cold Spring Harbor perspectives in medicine · 2016Review
- Article
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6 authors.
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Abstract
Transposon Tn558 integrated in the chromosomal radC gene was detected for the first time in Staphylococus pseudintermedius. It carried a novel fexA variant (fexAv) that confers only chloramphenicol resistance. The exporter FexAv exhibited two amino acid substitutions, Gly33Ala and Ala37Val, both of which seem to be important for substrate recognition. Site-directed mutagenesis that reverted the mutated base pairs to those present in the original fexA gene restored the chloramphenicol-plus-florfenicol resistance phenotype.
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