ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2013
Therapeutic potential of biodegradable microparticles containing Punica granatum L. (pomegranate) in murine model of asthma.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- IsLife (Basel, Switzerland) · 2025Article
- Anti-COVID-19 Potential of Ellagic Acid and Polyphenols ofMolecules (Basel, Switzerland) · 2023Review
- Valorization ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Pomegranate: A review of the heavenly healer's past, present, and future.Iranian journal of basic medical sciences · 2023Review
- Recent Advances in Nanomaterials for Asthma Treatment.International journal of molecular sciences · 2022Review
- Immunomodulatory Activity of Punicalagin, Punicalin, and Ellagic Acid Differs from the Effect of Pomegranate Peel Extract.Molecules (Basel, Switzerland) · 2022Article
- Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases.Molecules (Basel, Switzerland) · 2022Review
- Nutraceuticals for Complementary Treatment of Multisystem Inflammatory Syndrome in Children: A Perspective from Their Use in COVID-19.Life (Basel, Switzerland) · 2022Review
- Immunomodulatory Properties of Pomegranate Peel Extract in a Model of Human Peripheral Blood Mononuclear Cell Culture.Pharmaceutics · 2022Article
- Previously published ethno-pharmacological reports reveal the potentiality of plants and plant-derived products used as traditional home remedies by Bangladeshi COVID-19 patients to combat SARS-CoV-2.Saudi journal of biological sciences · 2021Article
- Inhalation of sustained release microparticles for the targeted treatment of respiratory diseases.Drug delivery and translational research · 2020Review
- Pharmaceutical Benefits of Fluticasone Propionate Association to Delivery Systems: In Vitro and In Vivo Evaluation.Pharmaceutics · 2019Article
- Inhibition of MAPK and STAT3-SOCS3 by Sakuranetin Attenuated Chronic Allergic Airway Inflammation in Mice.Mediators of inflammation · 2019Article
- GalloylFrontiers in immunology · 2019Article
- Article
- Review
- Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases.Mediators of inflammation · 2016Review
- Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designAmong the options for treatment of diseases affecting the respiratory system, especially asthma, drug delivering systems for intranasal application represent an important therapeutic approach at the site of inflammation. The present study aimed to evaluate the therapeutic effect of biodegradable microparticles formed by poly lactic-co-glycolic acid (PLGA) containing encapsulated pomegranate extract on a murine model of asthma. MATERIAL: The extract was acquired from the leaves of P. granatum and characterized qualitatively by HPLC. A w/o/w emulsion solvent extraction-evaporation method was chosen to prepare the microparticles containing pomegranate encapsulated extract (MP). TREATMENT: OVA-sensitized BALB/c mice were used as asthma model and treated with dexamethasone and P. granatum extract in solution form or encapsulated into microparticles.
resultsMP were able to inhibit leukocytes' recruitment to bronchoalveolar fluid, especially, eosinophils, decreasing cytokines (IL-1β and IL-5) and protein levels in the lungs.
conclusionsThis approach can be used as an alternative/supplementary therapy based on the biological effects of P. granatum for managing inflammatory processes, especially those with pulmonary complications.
Indexed as
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23979691What OpenQuestion holds
Registered trials
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