ArticleGenetics2013
Nutritional control of epigenetic processes in yeast and human cells.
Article in Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Sex-Specific Associations between One-Carbon Metabolism Indices and Posttranslational Histone Modifications in Arsenic-Exposed Bangladeshi Adults.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Trial
- Effects of Free and Conjugated Methionine on Growth, Meat Quality, Mineral Profile, and Shell Strength in Garden Snails (Animals : an open access journal from MDPI · 2025Article
- Evolutionary Trajectory ofBiomedicines · 2025Review
- The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux.PloS one · 2025Article
- Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia.Cellular & molecular immunology · 2024Article
- Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing.Nature metabolism · 2024Article
- The human malaria parasiteProceedings of the National Academy of Sciences of the United States of America · 2023Article
- One-Carbon and Polyamine Metabolism as Cancer Therapy Targets.Biomolecules · 2022Review
- Protein Supplementation during Mid-Gestation Alters the Amino Acid Patterns, Hepatic Metabolism, and Maternal Skeletal Muscle Turnover of Pregnant Zebu Beef Cows.Animals : an open access journal from MDPI · 2022Article
- Epi-Drugs in Heart Failure.Frontiers in cardiovascular medicine · 2022Review
- H3K4 Methylation in Aging and Metabolism.Epigenomes · 2021Review
- Epigenetics in Cardiac Hypertrophy and Heart Failure.JACC. Basic to translational science · 2019Review
- Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Impact of One Carbon Metabolism on Histone Methylation.Frontiers in genetics · 2019Review
- Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism.Trends in endocrinology and metabolism: TEM · 2018Review
- Metabolic regulation of chromatin modifications and gene expression.The Journal of cell biology · 2018Review
- Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction.Brain, behavior, and immunity · 2018Article
- Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer.Frontiers in genetics · 2018Review
- S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Mitochondrial-epigenetic crosstalk in environmental toxicology.Toxicology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The vitamin folate is required for methionine homeostasis in all organisms. In addition to its role in protein synthesis, methionine is the precursor to S-adenosyl-methionine (SAM), which is used in myriad cellular methylation reactions, including all histone methylation reactions. Here, we demonstrate that folate and methionine deficiency led to reduced methylation of lysine 4 of histone H3 (H3K4) in Saccharomyces cerevisiae. The effect of nutritional deficiency on H3K79 methylation was less pronounced, but was exacerbated in S. cerevisiae carrying a hypomorphic allele of Dot1, the enzyme responsible for H3K79 methylation. This result suggested a hierarchy of epigenetic modifications in terms of their susceptibility to nutritional limitations. Folate deficiency caused changes in gene transcription that mirrored the effect of complete loss of H3K4 methylation. Histone methylation was also found to respond to nutritional deficiency in the fission yeast Schizosaccharomyces pombe and in human cells in culture.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.