ArticleVirchows Archiv : an international journal of pathology2013
Neuroendocrine carcinoma in a mediastinal teratoma as a rare variant of somatic-type malignancy.
Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- En bloc resection of an extremely giant mediastinal immature teratoma with somatic-type malignancy: A case report with a brief review of the literature.Clinical case reports · 2024Article
- Mediastinal high-grade vasculogenic mesenchymal tumour with seminoma: a case report and literature review.Diagnostic pathology · 2023Review
- Mediastinal mass in a young man with a previous history of dermatofibrosarcoma protuberans: metastatic disease or different entity-a case report.Mediastinum (Hong Kong, China) · 2021Article
- Neuroendocrine tumors of the thymus and mediastinum.Journal of thoracic disease · 2017Review
- Primary atypical carcinoid tumor of the mediastinum: a very rare finding.Journal of thoracic disease · 2017Article
- [Mediastinal germ cell tumors].Der Pathologe · 2016Review
- Mediastinal Teratoma with Coexisting Adenocarcinoma and Carcinoid Tumor (Somatic-Type Malignancy): A Case Report with a Review of the Literature.Turkish thoracic journal · 2015Article
- Mediastinal Teratoma with Neuroendocrine Features in 34-Year-Old Male with Syncope.Case reports in surgery · 2015Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
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Abstract
Somatic-type malignancy (STM), defined as any sarcoma, carcinoma, leukemia or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. Neuroendocrine carcinoma developing in a mediastinal germ cell tumor has not been previously reported. We here describe a 22-year-old man who underwent resection of a 11-cm mediastinal teratoma which consisted of components of all three germ cell layers with prominent foci of fetal-like liver tissue. The liver areas were surrounded by primitive neuroendocrine structures with ductal and solid growth pattern with a high proliferation rate. We diagnosed an immature mediastinal teratoma with STM, specifically neuroendocrine carcinoma arising in a background of immature liver tissue. Comparative genomic hybridization of dissected tumor tissue revealed chromosomal gains at 12 in the teratoma and neuroendocrine carcinoma component. In summary, clinicians and pathologists should be aware of neuroendocrine carcinoma as a rare type of STM complicating mediastinal germ cell tumors.
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