ArticleVirchows Archiv : an international journal of pathology2013
Increased expression of Trop2 correlates with poor survival in extranodal NK/T cell lymphoma, nasal type.
Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis.Scientific reports · 2016Pooled it
- The role of tacstd-2 level in hepatitis C patients (controlled clinical research).The Libyan journal of medicine · 2019Trial
- Trophoblast Cell Surface Antigen 2 (Trop2) Is Expressed in Cases of EBV-Positive Diffuse Large B-Cell Lymphoma Emerging from Angioimmunoblastic T-Cell Lymphoma.Reports (MDPI) · 2024Article
- Prognostic significance of trophoblastic cell surface antigen 2 expression and pathologic parameters in patients with ampullary adenocarcinoma.Human pathology · 2023Article
- Expression of fatty acid-binding protein-4 in gastrointestinal stromal tumors and its significance for prognosis.Journal of clinical laboratory analysis · 2021Article
- Towards Next Generation Biomarkers in Natural Killer/T-Cell Lymphoma.Life (Basel, Switzerland) · 2021Review
- Trop2: Jack of All Trades, Master of None.Cancers · 2020Review
- High expression of NDRG3 associates with unfavorable overall survival in non-small cell lung cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.Disease markers · 2018Article
- The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma.Oncology letters · 2017Article
- Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways.BMC cancer · 2017Article
- A neutralized human LMP1-IgG inhibits ENKTL growth by suppressing the JAK3/STAT3 signaling pathway.Oncotarget · 2017Article
- Prognostic role and clinical significance of trophoblast cell surface antigen 2 in various carcinomas.Cancer management and research · 2017Article
- High Expression of PHGDH Predicts Poor Prognosis in Non-Small Cell Lung Cancer.Translational oncology · 2016Article
- The tumor-inhibitory effectiveness of a novel anti-Trop2 Fab conjugate in pancreatic cancer.Oncotarget · 2016Article
- Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications.Genes & cancer · 2015Review
- Elevated expression of CRYAB predicts unfavorable prognosis in non-small cell lung cancer.Medical oncology (Northwood, London, England) · 2014Article
- ROR1 expression correlated with poor clinical outcome in human ovarian cancer.Scientific reports · 2014Article
- High expression of inositol polyphosphate phosphatase-like 1 associates with unfavorable survival in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2013Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human trophoblastic cell surface antigen 2 (Trop2) has been suggested to play an important role in the development of solid tumors. However, the expression of Trop2 in extranodal NK/T cell lymphoma, nasal type (ENKTL) and the relationship with the clinical characteristics of this disease remain poorly understood. In this study, one-step quantitative PCR reverse transcription-polymerase chain reaction and immunohistochemical staining with tissue sections were employed to evaluate the expression of Trop2 in ENKTL. Furthermore, the relationship between Trop2 expression and prognosis of ENKTL was investigated. Expression of Trop2 mRNA and protein was significantly higher in ENKTL tissue than in corresponding non-lymphomatous tissue (p = 0.04 and p < 0.001, respectively). Expression of Trop2 protein in ENKTL was associated with lymph node involvement and poor overall survival (p = 0.045 and p = 0.018, respectively). Kaplan-Meier analysis and the logrank test indicated that lymph node involvement (p = 0.0481), single therapy strategy (p = 0.0037), and high expression of Trop2 (p = 0.0042) are significantly correlated with poor prognosis of ENKTL patients. The data suggest that Trop2 expression reflects a more malignant phenotype and may serve as an unfavorable prognostic factor for ENKTL.
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