ArticleScientific reports2013
Subdiffusion supports joining of correct ends during repair of DNA double-strand breaks.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Modelling Heterogeneous Anomalous Dynamics of Radiation-Induced Double-Strand Breaks in DNA during Non-Homologous End-Joining Pathway.Entropy (Basel, Switzerland) · 2024Article
- Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair.Radiation research · 2023Article
- Mechanistic Modelling of Slow and Fast NHEJ DNA Repair Pathways Following Radiation for G0/G1 Normal Tissue Cells.Cancers · 2021Article
- Differential Repair Protein Recruitment at Sites of Clustered and Isolated DNA Double-Strand Breaks Produced by High-Energy Heavy Ions.Scientific reports · 2020Article
- Quantifying site-specific chromatin mechanics and DNA damage response.Scientific reports · 2018Article
- DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage.Scientific reports · 2018Article
- Live Dynamics of 53BP1 Foci Following Simultaneous Induction of Clustered and Dispersed DNA Damage in U2OS Cells.International journal of molecular sciences · 2018Article
- In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density.Scientific reports · 2018Article
- Super-Resolution Localization Microscopy of γ-H2AX and Heterochromatin after Folate Deficiency.International journal of molecular sciences · 2017Article
- Single α-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites.Scientific reports · 2017Article
- Article
- Microirradiation techniques in radiobiological research.Journal of biosciences · 2015Review
- Review
- Live cell imaging at the Munich ion microbeam SNAKE - a status report.Radiation oncology (London, England) · 2015Review
- Article
- Chromatin dynamics during DNA repair revealed by pair correlation analysis of molecular flow in the nucleus.Biophysical journal · 2014Article
- The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.Journal of cellular physiology · 2014Review
- ATM alters the otherwise robust chromatin mobility at sites of DNA double-strand breaks (DSBs) in human cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mobility of damaged chromatin regions in the nucleus may affect the probability of mis-repair. In this work, live-cell observation and distance tracking of GFP-tagged DNA damage response protein MDC1 was used to study the random-walk behaviour of chromatin domains containing radiation-induced DNA double-strand breaks (DSB). Our measurements indicate a subdiffusion-type random walk process with similar time dependence for isolated and clustered DSBs that were induced by 20 MeV proton or 43 MeV carbon ion micro-irradiation. As compared to normal diffusion, subdiffusion enhances the probability that both ends of a DSB meet, thus promoting high efficiency DNA repair. It also limits their probability of long-range movements and thus lowers the probability of mis-rejoining and chromosome aberrations.
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