ArticleBioorganic & medicinal chemistry letters2013
Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.
Article in Bioorganic & medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.Journal of psychiatry & neuroscience : JPN · 2015Pooled it
- Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women.Translational psychiatry · 2017Trial
- Development and characterisation of novel oxytocin analogues for PET imaging.Communications chemistry · 2025Article
- Binding Affinity, Selectivity, and Pharmacokinetics of the Oxytocin Receptor Antagonist L-368,899 in the Coyote (Comparative medicine · 2024Article
- Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Using Receptor Autoradiography to Visualize and Quantify Oxytocin and Vasopressin 1a Receptors in the Human and Nonhuman Primate Brain.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study.Neuro-oncology · 2021Article
- Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain.Translational psychiatry · 2018Article
- Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem.Social neuroscience · 2017Article
- An evaluation of central penetration from a peripherally administered oxytocin receptor selective antagonist in nonhuman primates.Bioorganic & medicinal chemistry · 2017Article
- Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys.Bioorganic & medicinal chemistry letters · 2016Article
- Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications.Journal of neuroendocrinology · 2016Review
- The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders.Molecular psychiatry · 2016Review
- Oxytocin and social cognition in affective and psychotic disorders.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Review
- Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits.Frontiers in neuroscience · 2015Review
- Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus).Neuroscience · 2014Article
- The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta).Psychoneuroendocrinology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The compound 1-(1-(2-(2-(2-fluoroethoxy)-4-(piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one (1) was synthesized and positively evaluated in vitro for high potency and selectivity with human oxytocin receptors. The positron emitting analogue, [F-18]1, was synthesized and investigated in vivo via PET imaging using rat and cynomolgus monkey models. PET imaging studies in female Sprague-Dawley rats suggested [F-18]1 reached the brain and accumulated in various regions of the brain, but washed out too rapidly for adequate quantification and localization. In vivo PET imaging studies in a male cynomolgus monkey suggested [F-18]1 had limited brain penetration while specific uptake of radioactivity significantly accumulated within the vasculature of the cerebral ventricles in areas representative of the choroid plexus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.