Evidence map›Paper›PMID 23978562›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2013

Effects of intrathecal SNC80, a delta receptor ligand, on nociceptive threshold and dorsal horn substance p release.

Milad Kouchek, Toshifumi Takasusuki, Tetsuji Terashima, Tony L Yaksh, Qinghao Xu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Alleviating pain with delta opioid receptor agonists: evidence from experimental models.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Review
  4. A Novel G Protein-Biased Agonist at theThe Journal of pharmacology and experimental therapeutics · 2020
    Article
  5. Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat.Neuromodulation : journal of the International Neuromodulation Society · 2019
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Molecular Pharmacology of δ-Opioid Receptors.Pharmacological reviews · 2016
    Review
  11. Article
  12. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Milad KouchekDepartment of Anesthesiology, University of California San Diego, La Jolla, California (M.K., T.L.Y., Q.X.); Department of Pharmacology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (M.K.); and Department of Anesthesiology, Dokkyo Medical University, School of Medicine, Mibu, Tochigi Prefecture, Japan (T.Ta., T.Te.).
Toshifumi Takasusuki
Tetsuji Terashima
Tony L Yaksh
Qinghao Xu
University of California, San Diego · USUniversity of Gothenburg · SEDokkyo Medical University · JP

Funding

The Pharmacology of Spinal AnalgesicsR01DA002110 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 1985 to 2014
$3.8M
NIDA NIH HHS DA02110NIDA NIH HHS R01 DA002110
6 · The paper itself

Abstract

Delta-opioid receptors (DOR) are present in the superficial dorsal horn and are believed to regulate the release of small afferent transmitters as evidenced by the effects of spinally delivered delta-opioid preferring peptides. Here we examined the effects of intrathecal SNC80 [(+)-4-[α(R)-α-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-3-(methoxybenzyl)-N,N-diethylbenzamide], a selective nonpeptidic DOR agonist, in three preclinical pain models, acute thermal escape, intraplantar carrageenan-tactile allodynia, and intraplantar formalin flinches, and on the evoked release of substance P (SP) from small primary afferents. Rats with chronic intrathecal catheters received intrathecal vehicle or SNC80 (100 or 200 μg). Intrathecal SNC80 did not change acute thermal latencies or carrageenan-induced thermal hyperalgesia. However, SNC80 attenuated carrageenan-induced tactile allodynia and significantly reduced both phase 1 and phase 2 formalin-induced paw flinches, as assessed by an automatic flinch counting device. These effects were abolished by naltrindole (3 mg/kg i.p.), a selective DOR antagonist, but not CTOP (10 µg i.t.), a selective MOR antagonist. Furthermore, intrathecal SNC80 (200 μg) blocked formalin-induced substance P release otherwise evoked in the ispilateral superficial dorsal horn as measured by NK1 receptor internalization. In conclusion, intrathecal SNC80 alleviated pain hypersensitivity after peripheral inflammation in a fashion paralleling its ability to block peptide transmitter release from small peptidergic afferents, which by its pharmacology appears to represent an effect mediated by a spinal DOR.

Indexed as

AnimalsBenzamidesDisease Models, AnimalInjections, SpinalLigandsMalePainPain ThresholdPiperazinesPosterior Horn CellsRatsRats, Sprague-DawleyReceptors, Neurokinin-1Receptors, Opioid, deltaSubstance P4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamideBenzamidesLigandsPiperazinesReceptors, Neurokinin-1Receptors, Opioid, deltaSubstance P

Identifiers

PMID23978562
PMCPMC3807063
OpenAlexW2164041316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.