Evidence map›Paper›PMID 23978501›Full record

ReviewPharmacology, biochemistry, and behavior2014

The neural and genetic basis of executive function: attention, cognitive flexibility, and response inhibition.

Sheree F Logue, Thomas J Gould

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacology, biochemistry, and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 6 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 6 syntheses or guidelines pooled it, 459 citations in OpenAlex.

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  19. Neurocognitive and Socio-Emotional Profile of Children with 22q11.2 Deletion Syndrome: Executive Functions, Social Processing Deficits and Clinical Implications.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026
    Review
  20. Article

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sheree F LogueDepartment of Psychology, Temple University, 6th Floor Main Office, Weiss Hall, 1701 North 13th Street, Philadelphia, PA 19122-6085, United States. Electronic address: sheree.logue@temple.edu.
Thomas J GouldDepartment of Psychology, Temple University, 6th Floor Main Office, Weiss Hall, 1701 North 13th Street, Philadelphia, PA 19122-6085, United States. Electronic address: tgould@temple.edu.
Temple University · US

Funding

Nicotine Addiction: Learning, Neural &Genetic ProcessR01DA017949 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI GOULD, THOMAS J · 2005 to 2015
$2.7M
Genetic, Behavioral, & Neurobiological Substrates of Nicotine WithdrawalR01DA024787 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI GOULD, THOMAS J · 2008 to 2012
$1.7M
NIDA NIH HHS DA017949NIDA NIH HHS DA024787NIDA NIH HHS R01 DA017949NIDA NIH HHS R01 DA024787
6 · The paper itself

Abstract

Executive function is a collection of cognitive processes essential for higher order mental function. Processes involved in executive function include, but are not limited to, working memory, attention, cognitive flexibility, and impulse control. These complex behaviors are largely mediated by prefrontal cortical function but are modulated by dopaminergic, noradrenergic, serotonergic, and cholinergic input. The ability of these neurotransmitter systems to modulate executive function allows for adaptation in cognitive behavior in response to changes in the environment. Because of the important role these neurotransmitter systems play in regulating executive function, changes in these systems can also have a grave impact on executive function. In addition, polymorphisms in genes associated with these neurotransmitters are associated with phenotypic differences in executive function. Understanding how these naturally occurring polymorphisms contribute to different executive function phenotypes will advance basic knowledge of cognition and potentially further understanding and treatment of mental illness that involve changes in executive function. In this review, we will examine the influence of dopamine, norepinephrine, serotonin, and acetylcholine on the following measures of executive function: attention, cognitive flexibility, and impulse control. We will also review the effects of polymorphisms in genes associated with these neurotransmitter systems on these measures of executive function.

Indexed as

AttentionCognitionExecutive FunctionCholineHumansNorepinephrinePolymorphism, GeneticPrefrontal CortexSerotoninSynaptic TransmissionCholineNorepinephrineSerotoninAcetylcholineCognitionDopamineImpulsivityNorepinephrinePrefrontal cortex

Identifiers

PMID23978501
PMCPMC3933483
OpenAlexW2056919088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.