Trial reportCOPD2013
Severe chronic bronchitis in advanced emphysema increases mortality and hospitalizations.
Trial report in COPD, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Pooled it
- Determinants of exacerbation risk in patients with COPD in the TIOSPIR study.International journal of chronic obstructive pulmonary disease · 2017Trial
- Exploring Relevance of Graded Sputum Production in Stable COPD in Clinical Practice.International journal of chronic obstructive pulmonary disease · 2026Article
- Association of body mass index and COPD exacerbation among patients with chronic bronchitis.Respiratory research · 2022Observational
- Article
- Chronic Bronchitis: Where Are We Now?Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Article
- CAT Score and SGRQ Definitions of Chronic Bronchitis as an Alternative to the Classical Definition.International journal of chronic obstructive pulmonary disease · 2019Article
- Epidemiology of chronic airway disease: results from a cross-sectional survey in Beijing, China.Journal of thoracic disease · 2018Article
- Alternative definitions of chronic bronchitis and their correlation with CT parameters.International journal of chronic obstructive pulmonary disease · 2018Article
- Chronic bronchitis is associated with severe exacerbation and prolonged recovery period in Chinese patients with COPD: a multicenter cross-sectional study.Journal of thoracic disease · 2017Article
- Dendritic Cell-Airway Epithelial Cell Cross-Talk Changes with Age and Contributes to Chronic Lung Inflammatory Diseases in the Elderly.International journal of molecular sciences · 2017Review
- The therapeutic potential of CFTR modulators for COPD and other airway diseases.Current opinion in pharmacology · 2017Review
- Therapeutic Approaches to Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis.Annals of the American Thoracic Society · 2016Review
- Free light chains: potential biomarker and predictor of mortality in alpha-1-antitrypsin deficiency and usual COPD.Respiratory research · 2016Article
- The chronic bronchitis phenotype in chronic obstructive pulmonary disease: features and implications.Current opinion in pulmonary medicine · 2015Review
- Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene.Annals of the American Thoracic Society · 2015Observational
- Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Article
- Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study.Respiratory research · 2014Observational
- Preventing COPD exacerbations: new options for a crucial and growing problem.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2014Article
- Clinical Impact of the Bronchiectasis with Chronic Bronchitis Symptoms in COPD: Analysis of a Longitudinal Cohort.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundChronic bronchitis in COPD has been associated with an increased exacerbation rate, more hospitalizations, and an accelerated decline in lung function. The clinical characteristics of patients with advanced emphysema and chronic bronchitis have not been well described.
methodsPatients randomized to medical therapy in the National Emphysema Treatment Trial were grouped based on their reports of cough and phlegm on the St. George's Respiratory Questionnaire(SGRQ) at baseline: chronic bronchitis(CB+) and no chronic bronchitis(CB-). The patients were similarly categorized into severe chronic bronchitis(SCB+) or no severe chronic bronchitis (SCB-) based on the above definition plus report of chest trouble. Kaplan-Meier survival analysis was used to determine the relationships between chronic bronchitis and severe chronic bronchitis and survival and time to hospitalization. Lung function and SGRQ scores over time were compared between groups.
resultsThe CB+(N = 234; 38%) and CB- groups(N = 376; 62%) had similar survival (median 60.8 versus 65.7 months, p = 0.19) and time to hospitalization (median 26.9 versus 24.9 months, p = 0.84). The SCB+ group(N = 74; 12%) had worse survival (median 47.7 versus 65.7 months, p = 0.02) and shorter time to hospitalization (median 18.5 versus 26.7 months, p = 0.02) than the SCB- group (N = 536; 88%). Mortality and hospitalization rates were not increased when chest trouble was analyzed by itself. The CB+ and CB-groups had similar lung function and SGRQ scores over time. The SCB+ and SCB-groups had similar lung function over time, but the SCB+ group had significantly worse SGRQ scores.
conclusionsSevere chronic bronchitis is associated with worse survival, shorter time to hospitalization, and worse health-related quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.