ArticleNeuroImage. Clinical2013
Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder.
Article in NeuroImage. Clinical, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- The Status of Irritability in Psychiatry: A Conceptual and Quantitative Review.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Pooled it
- An Open Pilot Study of Training Hostile Interpretation Bias to Treat Disruptive Mood Dysregulation Disorder.Journal of child and adolescent psychopharmacology · 2016Trial
- Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control.Biological psychiatry global open science · 2025Article
- Irritability in stroke: a protocol for a prospective study.Frontiers in neurology · 2024Article
- Presentation and Management of Acute Mania in Fanconi-Bickel Syndrome, A Metabolic Genetic Disorder.Case reports in psychiatry · 2024Article
- Mediating effect of amygdala activity on response to fear vs. happiness in youth with significant levels of irritability and disruptive mood and behavior disorders.Frontiers in behavioral neuroscience · 2023Review
- Underlying mechanisms of disruptive mood dysregulation disorder in children: A systematic review by means of research domain criteria.JCPP advances · 2022Review
- The centrality of temperament to the research domain criteria (RDoC): The earliest building blocks of psychopathology.Development and psychopathology · 2021Article
- Face Emotion Processing in Pediatric Irritability: Neural Mechanisms in a Sample Enriched for Irritability With Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Longitudinal associations between amygdala reactivity and cannabis use in a large sample of adolescents.Psychopharmacology · 2020Article
- Attention shifting in the context of emotional faces: Disentangling neural mechanisms of irritability from anxiety.Depression and anxiety · 2020Article
- Multi-method assessment of irritability and differential linkages to neurophysiological indicators of attention allocation to emotional faces in young children.Developmental psychobiology · 2020Article
- Deficits in emotion recognition are associated with depressive symptoms in youth with disruptive mood dysregulation disorder.Depression and anxiety · 2018Article
- Reliability of neural activation and connectivity during implicit face emotion processing in youth.Developmental cognitive neuroscience · 2018Article
- Neurophysiological Processing of Emotion in Children of Mothers with a History of Depression: the Moderating Role of Preschool Persistent Irritability.Journal of abnormal child psychology · 2017Article
- Irritability in Youths: A Translational Model.The American journal of psychiatry · 2017Review
- Irritability in Children and Adolescents.Annual review of clinical psychology · 2017Review
- Pediatric Irritability: A Systems Neuroscience Approach.Trends in cognitive sciences · 2017Review
- Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology.JAMA psychiatry · 2017Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
A major controversy in child psychiatry is whether bipolar disorder (BD) presents in children as severe, non-episodic irritability (operationalized here as severe mood dysregulation, SMD), rather than with manic episodes as in adults. Both classic, episodic BD and SMD are severe mood disorders characterized by deficits in processing emotional stimuli. Neuroimaging techniques can be used to test whether the pathophysiology mediating these deficits are similar across the two phenotypes. Amygdala dysfunction during face emotion processing is well-documented in BD, but little is known about amygdala dysfunction in chronically irritable youth. We compared neural activation in SMD (n=19), BD (n=19), and healthy volunteer (HV; n=15) youths during an implicit face-emotion processing task with angry, fearful and neutral expressions. In the right amygdala, both SMD and BD exhibited greater activity across all expressions than HV. However, SMD and BD differed from each other and HV in posterior cingulate cortex, posterior insula, and inferior parietal lobe. In these regions, only SMD showed deactivation in response to fearful expressions, whereas only BD showed deactivation in response to angry expressions. Thus, during implicit face emotion processing, youth with BD and those with SMD exhibit similar amygdala dysfunction but different abnormalities in regions involved in information monitoring and integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.