ArticleWorld journal of biological chemistry2013
Autophagy and cancer.
Article in World journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed.
- Autologous blood transfusion promotes autophagy and inhibits hepatocellular carcinoma progression through HIF-1α signalling pathway.Journal of cellular and molecular medicine · 2023Article
- Pharmacological Activities of Ginkgolic Acids in Relation to Autophagy.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Suppression of Ribose-5-Phosphate Isomerase a Induces ROS to Activate Autophagy, Apoptosis, and Cellular Senescence in Lung Cancer.International journal of molecular sciences · 2022Article
- A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.Cell death & disease · 2019Article
- Differential effects of ginkgol C17:1 on cisplatin-induced cytotoxicity: Protecting human normal L02 hepatocytes versus sensitizing human hepatoma HepG2 cells.Oncology letters · 2019Article
- Diet Modulation Restores Autophagic Flux in Damaged Skeletal Muscle Cells.The journal of nutrition, health & aging · 2019Article
- Effects of ginkgol C17:1 on cisplatin-induced autophagy and apoptosis in HepG2 cells.Oncology letters · 2018Article
- Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease.Oxidative medicine and cellular longevity · 2016Review
- Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy.Oxidative medicine and cellular longevity · 2016Review
- Mitophagy mechanisms and role in human diseases.The international journal of biochemistry & cell biology · 2014Review
- Lithium improves survival of PC12 pheochromocytoma cells in high-density cultures and after exposure to toxic compounds.International journal of cell biology · 2014Article
- Autophagy Modulation in Disease Therapy: Where Do We Stand?Current pathobiology reports · 2013Article
- Cathepsins mediate tumor metastasis.World journal of biological chemistry · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Autophagy is a homeostatic and evolutionarily conserved mechanism of self-digestion by which the cells degrade and recycle long-lived proteins and excess or damaged organelles. Autophagy is activated in response to both physiological and pathological stimuli including growth factor depletion, energy deficiency or the upregulation of Bcl-2 protein expression. A novel role of autophagy in various cancers has been proposed. Interestingly, evidence that supports both a positive and negative role of autophagy in the pathogenesis of cancer has been reported. As a tumor suppression mechanism, autophagy maintains genome stability, induces senescence and possibly autophagic cell death. On the other hand, autophagy participates in tumor growth and maintenance by supplying metabolic substrate, limiting oxidative stress, and maintaining cancer stem cell population. It has been proposed that the differential roles of autophagy in cancer are disease type and stage specific. In addition, substrate selectivity might be involved in carrying out the specific effect of autophagy in cancer, and represents one of the potential directions for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.