ArticlePloS one2013
Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Mechanistic Insights Into the Tumor-Driving and Diagnostic Roles of KCTD Family Genes in Ovarian Cancer: An Integrated In Silico and In Vitro Analysis.Cancer medicine · 2025Article
- The CRL3Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comprehensive pan-carcinoma analysis of ITGB1 distortion and its potential clinical significance for cancer immunity.Discover oncology · 2024Article
- IncreasedCancers · 2023Article
- KCTD10 functions as a tumor suppressor in hepatocellular carcinoma by triggering the Notch signaling pathway.American journal of translational research · 2023Article
- The emerging role of the KCTD proteins in cancer.Cell communication and signaling : CCS · 2021Review
- KCells · 2020Article
- Low ETV1 mRNA expression is associated with recurrence in gastrointestinal stromal tumors.Scientific reports · 2020Article
- KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders.CNS neuroscience & therapeutics · 2019Review
- Molecular biomarkers for prognosis of gastrointestinal stromal tumor.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- Haplotypes ofDisease markers · 2019Article
- Functional analysis of Cullin 3 E3 ligases in tumorigenesis.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Identification of novel therapeutic target genes and pathway in pancreatic cancer by integrative analysis.Medicine · 2017Article
- Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population.Lipids in health and disease · 2016Article
- SLITRK3 expression correlation to gastrointestinal stromal tumor risk rating and prognosis.World journal of gastroenterology · 2015Article
- TERT promoter mutations are a rare event in gastrointestinal stromal tumors.SpringerPlus · 2015Article
- CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling.Neoplasia (New York, N.Y.) · 2014Article
- KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.PloS one · 2014Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrognostic biomarkers are required for risk stratification therapy in the patients with gastrointestinal stromal tumor (GIST). In this study, we aimed to identify prognostic biomarkers in GIST. We assessed the prognostic value of E twenty-six variant 1 (ETV1), a recently identified transcription factor unique to GIST. We also examined the clinical utility and functions of its downstream gene, potassium channel tetramerization domain containing protein 10 (KCTD10).
methodsThe levels of ETV1 and KCTD10 were evaluated immunohistochemically in 112 patients with GIST treated at two hospitals. The functional properties of KCTD10 were examined by gene silencing assay in cultured GIST cells.
resultsImmunohistochemistry revealed that ETV1 expression in GIST had no prognostic significance. In contrast, the disease-free survival rate was 88.5% in patients with KCTD10-positive tumors and 55.8% in those with KCTD10-negative tumors (p <0.0001). KCTD10 was an independent prognostic factor (p <0.05). In the low-risk classification group, KCTD10 was significantly associated with favorable prognosis (p = 0.0008). Gene silencing of KCTD10 increased cell proliferation and invasion, suggesting that KCTD10 has a tumor-suppressive function.
conclusionsThe GIST-specific transcription factor ETV1 may have no prognostic potential, whereas its downstream gene KCTD10 is associated with a favorable prognosis. Our study indicated the novel prognostic utility of KCTD10 in GIST, and suggested its tumor-suppressive effects on GIST cells. Further validation studies of KCTD10 for clinical applications, and functional verification of KCTD10 for better understanding of molecular basis of malignant phenotypes are worth challenging in GIST.
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