ArticlePloS one2013
Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- UPR-Induced miR-616 Inhibits Human Breast Cancer Cell Growth and Migration by Targeting c-MYC.International journal of molecular sciences · 2023Article
- The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate.Biomedicines · 2021Review
- Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis.Life (Basel, Switzerland) · 2021Article
- Effect of Hypoxia-Induced MicroRNA-210 Expression on Cardiovascular Disease and the Underlying Mechanism.Oxidative medicine and cellular longevity · 2019Review
- PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells.Scientific reports · 2018Article
- Autophagy and the unfolded protein response promote profibrotic effects of TGF-βAmerican journal of physiology. Lung cellular and molecular physiology · 2018Article
- Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death.Oncotarget · 2018Article
- Effect of dietary components on miRNA and colorectal carcinogenesis.Cancer cell international · 2018Review
- Dicer protein levels elevated by mild hyperthermia promote a pro-survival phenotype.Oncotarget · 2017Article
- The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes.BMC genomics · 2017Article
- MitoKATP regulating HIF/miR210/ISCU signaling axis and formation of a positive feedback loop in chronic hypoxia-induced PAH rat model.Experimental and therapeutic medicine · 2017Article
- NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.Oncogene · 2016Article
- PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response.Scientific reports · 2015Article
- A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.Cell reports · 2015Article
- Endoplasmic reticulum dysfunction in Alzheimer's disease.Molecular neurobiology · 2015Review
- Deciphering the RNA landscape by RNAome sequencing.RNA biology · 2015Article
- Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM.FEBS open bio · 2014Article
- miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts.Cell & bioscience · 2014Article
- The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes.BioMed research international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown to act as haploinsufficient tumor suppressors. How the deregulation of miRNA biogenesis promotes tumor development is not clearly understood. Here we show that loss of miRNA biogenesis increased resistance to endoplasmic reticulum (ER) stress-induced cell death. We observed that HCT116 cells with a DICER hypomorphic mutation (Exn5/Exn5) or where DICER or DROSHA were knocked down were resistant to ER stress-induced cell death. Extensive analysis revealed little difference in the unfolded protein response (UPR) of WT compared to Exn5/Exn5 HCT116 cells upon ER stress treatment. However, analysis of the intrinsic apoptotic pathway showed that resistance occurred upstream of the mitochondria. In particular, BAX activation and dissipation of mitochondrial membrane potential was attenuated, and there was altered expression of BCL-2 family proteins. These observations demonstrate a key role for miRNAs as critical modulators of the ER stress response. In our model, downregulation of miRNA biogenesis delays ER stress-induced apoptosis. This suggests that disrupted miRNA biogenesis may contribute to cancer progression by inhibiting ER stress-induced cell death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.