ArticlePloS one2013
Prenatal methyl-donor supplementation augments colitis in young adult mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Decoding NEC: epigenetic biomarkers for risk stratification and prognosis.Pediatric research · 2026Article
- A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate.International journal of molecular sciences · 2025Review
- Association of dietary intake of folate, serum folate, and red blood cell folate with mortality risk in patients with depression: a population-based longitudinal cohort study.Journal of health, population, and nutrition · 2025Article
- INVITED COMMENTARY on Andersen S, et al. Developmental Windows of Environmental Vulnerability for Inflammatory Bowel Disease.Journal of pediatrics. Clinical practice · 2024Article
- Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review.Nutrients · 2023Review
- MaternalFASEB bioAdvances · 2022Article
- Nuclear receptors: a bridge linking the gut microbiome and the host.Molecular medicine (Cambridge, Mass.) · 2021Review
- Methyl-Donor Micronutrient for Gestating Sows: Effects on Gut Microbiota and Metabolome in Offspring Piglets.Frontiers in nutrition · 2021Article
- The effect ofJournal of diabetes and metabolic disorders · 2020Article
- Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn's disease.Scientific reports · 2020Article
- Outbreak of Murine Infection withmSphere · 2019Article
- Interactions between Host PPARs and Gut Microbiota in Health and Disease.International journal of molecular sciences · 2019Review
- Fecal microbiota transplantation: great potential with many challenges.Translational gastroenterology and hepatology · 2019Review
- Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto rats.The European journal of neuroscience · 2016Article
- Inflammatory Bowel Disease: Influence and Implications in Reproduction.Inflammatory bowel diseases · 2016Review
- Microbiome-Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases.Journal of pediatric gastroenterology and nutrition · 2016Review
- DNA methylation-associated colonic mucosal immune and defense responses in treatment-naïve pediatric ulcerative colitis.Epigenetics · 2014Article
- Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Inflammatory bowel diseases (IBD) have become highly prevalent in developed countries. Environmentally triggered exaggerated immune responses against the intestinal microbiome are thought to mediate the disorders. The potential dietary origins of the disease group have been implicated. However, the effects of environmental influences on prenatal developmental programming in respect to orchestrating postnatal microbiome composition and predilection towards mammalian colitis have not been examined. We tested how transient prenatal exposure to methyl donor micronutrient (MD) supplemented diets may impact predilection towards IBD in a murine dextran sulfate sodium (DSS) colitis model. Prenatal MD supplementation was sufficient to modulate colonic mucosal Ppara expression (3.2 fold increase; p=0.022) and worsen DSS colitis in young adulthood. The prenatal dietary exposure shifted the postnatal colonic mucosal and cecal content microbiomes. Transfer of the gut microbiome from prenatally MD supplemented young adult animals into germ free mice resulted in increased colitis susceptibility in the recipients compared to controls. Therefore, the prenatal dietary intervention induced the postnatal nurturing of a colitogenic microbiome. Our results show that prenatal nutritional programming can modulate the mammalian host to harbor a colitogenic microbiome. These findings may be relevant for the nutritional developmental origins of IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.