ArticlePloS one2013
Brain-immune interaction accompanying odor-evoked autobiographic memory.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system.PLoS biology · 2026Article
- Exploratory research on cognitive fluency design for the older adults through Nostalgia-based empowerment.Aging clinical and experimental research · 2026Review
- The Role of Perfumes in Surgical Wound Infections and Wound Healing: A Case-Control Study.International wound journal · 2026Article
- Music-Evoked Nostalgia Activates Default Mode and Reward Networks Across the Lifespan.Human brain mapping · 2025Article
- Harmonizing the past: EEG-based brain network unveil modality-specific mechanisms of nostalgia.Frontiers in psychology · 2025Article
- Inflammation and olfactory loss are associated with at least 139 medical conditions.Frontiers in molecular neuroscience · 2024Article
- Improvement of cognitive function in wild-type and Alzheimer´s disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells.Frontiers in immunology · 2023Article
- Patterns of brain activity associated with nostalgia: a social-cognitive neuroscience perspective.Social cognitive and affective neuroscience · 2022Article
- Olfactory Evaluation in Clinical Medical Practice.Journal of clinical medicine · 2022Review
- Nostalgia evocation through seasonality-conscious purchasing behavior revealed by online survey using vegetable names.Scientific reports · 2022Article
- A three-factor benefits framework for understanding consumer preference for scented household products: psychological interactions and implications for future development.Cognitive research: principles and implications · 2022Review
- Feeling Safe and Nostalgia in Healthy Aging.Frontiers in psychology · 2022Review
- Olfactory Virtual Reality: A New Frontier in the Treatment and Prevention of Posttraumatic Stress Disorder.Brain sciences · 2021Article
- Systemic inflammation is associated with differential neural reactivity and connectivity to affective images.Social cognitive and affective neuroscience · 2020Article
- An in-depth review of the methods, findings, and theories associated with odor-evoked autobiographical memory.Psychonomic bulletin & review · 2019Review
- The Role of Odor-Evoked Memory in Psychological and Physiological Health.Brain sciences · 2016Review
- Memory and reward systems coproduce 'nostalgic' experiences in the brain.Social cognitive and affective neuroscience · 2016Article
- NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation.The international journal of neuropsychopharmacology · 2015Article
- Olfactory LOVER: behavioral and neural correlates of autobiographical odor memory.Frontiers in psychology · 2014Article
- Development of a Nostalgic Remembering Intervention: Feeling Safe in Dyads Receiving Palliative Care for Advanced Heart Failure.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-γ concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions.
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