ArticlePloS one2013
Alcohol consumption and viral load are synergistically associated with CIN1.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- Emerging paradigms: unmasking the role of oxidative stress in HPV-induced carcinogenesis.Infectious agents and cancer · 2024Review
- Article
- Effect of Ethanol-Induced Methyl Donors Consumption on the State of Hypomethylation in Cervical Cancer.International journal of molecular sciences · 2023Article
- Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study.The Lancet regional health. Europe · 2022Article
- Early Mini-Invasive Treatment of Persistent Cervical Dysplasia: Clinical Outcome and Psycho-Relational Impact.Frontiers in surgery · 2022Article
- Article
- Sex differences in the prevalence and determinants of HPV-related external genital lesions in young adults: a national cross-sectional survey in Brazil.BMC infectious diseases · 2020Article
- Effects on Vaginal Microbiota Restoration and Cervical Epithelialization in Positive HPV Patients Undergoing Vaginal Treatment with Carboxy-Methyl-Beta-Glucan.BioMed research international · 2020Article
- Risk of cervical dysplasia among human papillomavirus-infected women in Korea: a multicenter prospective study.Journal of gynecologic oncology · 2019Article
- Combined Effect of Secondhand Smoking and Alcohol Drinking on Risk of Persistent Human Papillomavirus Infection.BioMed research international · 2019Article
- Cervical cancer screening among transactional female sex workers in the Dominican Republic.International journal of STD & AIDS · 2018Article
- Association Between Passive Smoking and the Risk of Cervical Intraepithelial Neoplasia 1 in Korean Women.Journal of epidemiology · 2018Article
- Alcohol Abuse Decreases Pelvic Control and Survival in Cervical Cancer: An Opportunity of Lifestyle Intervention for Outcome Improvement.American journal of clinical oncology · 2017Article
- Alcoholic Beverage Consumption and Chronic Diseases.International journal of environmental research and public health · 2016Review
- Association of Combined Tobacco Smoking and Oral Contraceptive Use With Cervical Intraepithelial Neoplasia 2 or 3 in Korean Women.Journal of epidemiology · 2016Article
- Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe investigated the association between alcohol consumption and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer, and determined whether these associations were modified by human papillomavirus (HPV) viral load in high-risk HPV-positive women participating in the Korean HPV cohort study (KHPV).
methodsAmong the women recruited in the KHPV (n = 1,243) from March 2006 to December 2009, we analyzed normal cytology (n = 581) as control group, CIN1 (n = 299), CIN2/3 (n = 161), or cervical cancer (n = 202). Multinomial logistic analysis was performed to estimate multivariate-adjusted odds ratios (OR).
resultsAlcohol drinkers had an increased risk of CIN1 (OR = 2.18, 95% CI 1.22-3.89) compared with non-drinkers after adjusting for potential confounders. Subjects with more frequent alcohol consumption had a higher risk of CIN1 (p for linear trend <0.0001). Higher ethanol consumption was associated with an increased risk of CIN1 (p for linear trend = 0.0001). We also observed a synergistic effect between HPV viral load and alcohol consumption: drinkers with a high HPV viral load (≥100 RLU/PC) were associated with a significantly increased risk of CIN1 (OR = 19.1; 95% CI, 6.60-55.3, interaction p<0.001). There were no associations between alcohol drinking and CIN2/3 or cervical cancer.
conclusionsHPV viral load and alcohol was associated with the risk of CIN1 among high-risk HPV-positive women. This is the first demonstration that alcohol is an independent and combined risk factor of CIN1.
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