ArticlePloS one2013
Differential modulation of TREM2 protein during postnatal brain development in mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- TREM2Frontiers in immunology · 2025Review
- Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development.Immunity · 2024Article
- Microglia in Ischemic Stroke: Pathogenesis Insights and Therapeutic Challenges.Journal of inflammation research · 2024Review
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- Resident macrophages of the lung and liver: The guardians of our tissues.Frontiers in immunology · 2022Review
- Trans-cardiac perfusion of neonatal mice and immunofluorescence of the whole body as a method to study nervous system development.PloS one · 2022Article
- The Role of Microglia in Modulating Neuroinflammation after Spinal Cord Injury.International journal of molecular sciences · 2021Review
- Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring.Brain, behavior, & immunity - health · 2021Article
- Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.International journal of molecular sciences · 2021Review
- Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet.Journal of neuroinflammation · 2020Article
- Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2020Article
- Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models.Frontiers in cellular neuroscience · 2020Article
- Unique microglia expression profile in developing white matter.BMC research notes · 2019Article
- Developmental roles of microglia: A window into mechanisms of disease.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- New insights into the role of TREM2 in Alzheimer's disease.Molecular neurodegeneration · 2018Review
- Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain.Neurobiology of aging · 2018Article
- Microglial dynamics during brain development.Neural regeneration research · 2018Article
- TREM2 in Neurodegenerative Diseases.Molecular neurodegeneration · 2017Review
- Sex differences in microglial phagocytosis in the neonatal hippocampus.Brain, behavior, and immunity · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During postnatal development, microglia, the resident innate immune cells of the central nervous system are constantly monitoring the brain parenchyma, cleaning the cell debris, the synaptic contacts overproduced and also maintaining the brain homeostasis. In this context, the postnatal microglia need some control over the innate immune response. One such molecule recently described to be involved in modulation of immune response is TREM2 (triggering receptor expressed on myeloid cells 2). Although some studies have observed TREM2 mRNA in postnatal brain, the regional pattern of the TREM2 protein has not been described. We therefore characterized the distribution of TREM2 protein in mice brain from Postnatal day (P) 1 to 14 by immunostaining. In our study, TREM2 protein was expressed only in microglia/macrophages and is developmentally downregulated in a region-dependent manner. Its expression persisted in white matter, mainly in caudal corpus callosum, and the neurogenic subventricular zone for a longer time than in grey matter. Additionally, the phenotypes of the TREM2+ microglia also differ; expressing CD16/32, MHCII and CD86 (antigen presentation markers) and CD68 (phagocytic marker) in different regions as well as with different intensity till P7. The mannose receptor (CD206) colocalized with TREM2 only at P1-P3 in the subventricular zone and cingulum, while others persisted at low intensities till P7. Furthermore, the spatiotemporal expression pattern and characterization of TREM2 indicate towards its other plausible roles in phagocytosis, progenitor's fate determination or microglia phenotype modulation during postnatal development. Hence, the increase of TREM2 observed in pathologies may recapitulate their function during postnatal development, as a better understanding of this period may open new pathway for future therapies.
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