ArticlePloS one2013
Hyperlipidemia impaired innate immune response to periodontal pathogen porphyromonas gingivalis in apolipoprotein E knockout mice.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2 citations in OpenAlex.
- Meta-analysis on the association between the frequency of tooth brushing and hypertension risk.Journal of clinical hypertension (Greenwich, Conn.) · 2022Pooled it
- [Association between chronic periodontitis and hyperlipidemia: a Meta-analysis based on observational studies].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Pooled it
- Symptomatic Trends and Time to Recovery for Long COVID Patients Infected During the Omicron Phase.Journal of clinical medicine · 2025Article
- Association between Dietary Live Microbe Intake and Periodontitis in Adults: Evidence from NHANES.Oral health & preventive dentistry · 2025Article
- Interlinked Pathways: Exploring the Bidirectional Impacts of Periodontitis and Metabolic Syndrome.Cureus · 2024Review
- Periodontal pathogens and obesity in the context of cardiovascular risks across age groups.Frontiers in oral health · 2024Article
- Association between weight-adjusted-waist index and periodontitis risk: A cross-sectional study.PloS one · 2024Article
- Triglyceride induces DNA damage leading to monocyte death by activating caspase-2 and caspase-8.BMB reports · 2023Article
- Association between oral health behavior and chronic diseases among middle-aged and older adults in Beijing, China.BMC oral health · 2023Article
- Article
- OralBiomedicines · 2022Article
- Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses.Frontiers in cardiovascular medicine · 2022Article
- Association between metabolic and hormonal profile, proinflammatory cytokines in saliva and gingival health in adolescent females with polycystic ovary syndrome.BMC oral health · 2021Article
- Subgingival microflora in adolescent females with polycystic ovary syndrome and its association with oral hygiene, gingivitis, and selected metabolic and hormonal parameters.Clinical oral investigations · 2021Article
- Screening of Genetic Factor in the Interaction Between Periodontitis and Metabolic Traits Using Candidate Gene Association Study (CGAS).Biochemical genetics · 2019Article
- A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses.mBio · 2018Article
- Restoration of Declined Immune Responses and Hyperlipidemia byBiomolecules & therapeutics · 2017Article
- The promotion of nephropathy byDiabetology & metabolic syndrome · 2017Article
- Lipoprotein lipase deficiency presenting with neonatal perianal abscesses.BMJ case reports · 2016Review
- Association between toothbrushing and risk factors for cardiovascular disease: a large-scale, cross-sectional Japanese study.BMJ open · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A finely-tuned innate immune response plays a pivotal role in protecting host against bacterial invasion during periodontal disease progression. Hyperlipidemia has been suggested to exacerbate periodontal health condition. However, the underlying mechanism has not been addressed. In the present study, we investigated the effect of hyperlipidemia on innate immune responses to periodontal pathogen Porphyromonas gingivalis infection. Apolipoprotein E-deficient and wild-type mice at the age of 20 weeks were used for the study. Peritoneal macrophages were isolated and subsequently used for the study of viable P. gingivalis infection. ApoE(-/-) mice demonstrated inhibited iNOS production and impaired clearance of P. gingivalis in vitro and in vivo; furthermore, ApoE(-/-) mice displayed disrupted cytokine production pattern in response to P. gingivalis, with a decreased production of tumor necrosis factor-α, interleukin-6 (IL-6), IL-1β and monocyte chemotactic protein-1. Microarray data demonstrated that Toll-like receptor (TLR) and NOD-like receptor (NLR) pathway were altered in ApoE(-/-) mice macrophages; further analysis of pattern recognition receptors (PRRs) demonstrated that expression of triggering receptors on myeloid cells-1 (TREM-1), an amplifier of the TLR and NLR pathway, was decreased in ApoE(-/-) mice macrophages, leading to decreased recruitment of NF-κB onto the promoters of the TNF-α and IL-6. Our data suggest that in ApoE(-/-) mice hyperlipidemia disrupts the expression of PRRs, and cripples the host's capability to generate sufficient innate immune response to P. gingivalis, which may facilitate immune evasion, subgingival colonization and establishment of P. gingivalis in the periodontal niche.
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