ArticlePloS one2013
Rotavirus seasonality and age effects in a birth cohort study of southern India.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Investigating seasonal patterns in enteric infections: a systematic review of time series methods.Epidemiology and infection · 2022Pooled it
- Untangling the Impacts of Climate Change on Waterborne Diseases: a Systematic Review of Relationships between Diarrheal Diseases and Temperature, Rainfall, Flooding, and Drought.Environmental science & technology · 2016Pooled it
- Seasonality of underweight among infants 1-11 months old in Niger: an exploratory analysis of data from a cluster-randomised trial.BMJ global health · 2025Trial
- Genotype Distribution of Rotavirus Strains and Its Association with Severity of Diarrhea Among Children Under Five Hospitalized with Acute Gastroenteritis in Odisha, India: Authors' Reply.Indian journal of pediatrics · 2026Article
- Article
- Growth dynamics of Indian infants using latent trajectory models in pooled survey datasets.Frontiers in public health · 2024Article
- How Seasonality of Malnutrition Is Measured and Analyzed.International journal of environmental research and public health · 2021Review
- Effects of Data Aggregation on Time Series Analysis of Seasonal Infections.International journal of environmental research and public health · 2020Article
- Assessing Seasonality Variation with Harmonic Regression: Accommodations for Sharp Peaks.International journal of environmental research and public health · 2020Article
- Pathogen-Specific Impacts of the 2011-2012 La Niña-Associated Floods on Enteric Infections in the MAL-ED Peru Cohort: A Comparative Interrupted Time Series Analysis.International journal of environmental research and public health · 2020Article
- Rotavirus Seasonality: An Application of Singular Spectrum Analysis and Polyharmonic Modeling.International journal of environmental research and public health · 2019Article
- The seasonality of diarrheal pathogens: A retrospective study of seven sites over three years.PLoS neglected tropical diseases · 2019Article
- Seasonality of Rotavirus Hospitalizations at Costa Rica's National Children's Hospital in 2010-2015.International journal of environmental research and public health · 2019Article
- Community-Based Participatory Research and Drug Utilization Research to Improve Childhood Diarrhea Case Management in Ujjain, India: A Cross-Sectional Survey.International journal of environmental research and public health · 2019Article
- Seasonality and within-subject clustering of rotavirus infections in an eight-site birth cohort study.Epidemiology and infection · 2018Article
- Spatial and temporal patterns of diarrhoea in Bhutan 2003-2013.BMC infectious diseases · 2017Article
- Planning for climate change: The need for mechanistic systems-based approaches to study climate change impacts on diarrheal diseases.The Science of the total environment · 2016Article
- Seasonality of water quality and diarrheal disease counts in urban and rural settings in south India.Scientific reports · 2016Article
- Clinical epidemiology and molecular profiling of human bocavirus in faecal samples from children with diarrhoea in Guangzhou, China.Epidemiology and infection · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
introductionUnderstanding the temporal patterns in disease occurrence is valuable for formulating effective disease preventive programs. Cohort studies present a unique opportunity to explore complex interactions associated with emergence of seasonal patterns of infectious diseases.
methodsWe used data from 452 children participating in a birth cohort study to assess the seasonal patterns of rotavirus diarrhea by creating a weekly time series of rotavirus incidence and fitting a Poisson harmonic regression with biannual peaks. Age and cohort effects were adjusted for by including the weekly counts of number of children in the study and the median age of cohort in a given week. Weekly average temperature, humidity and an interaction term to reflect the joint effect of temperature and humidity were included to consider the effects of meteorological variables.
resultsIn the overall rotavirus time series, two significant peaks within a single year were observed--one in winter and the other in summer. The effect of age was found to be the most significant contributor for rotavirus incidence, showing a strong negative association. Seasonality remained a significant factor, even after adjusting for meteorological parameters, and the age and cohort effects.
conclusionsThe methodology for assessing seasonality in cohort studies is not yet developed. This is the first attempt to explore seasonal patterns in a cohort study with a dynamic denominator and rapidly changing immune response on individual and group levels, and provides a highly promising approach for a better understanding of the seasonal patterns of infectious diseases, tracking emergence of pathogenic strains and evaluating the efficacy of intervention programs.
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