ArticlePloS one2013
Preserving neural function under extreme scaling.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A connectome and analysis of the adulteLife · 2020Pooled it
- Neurons exploit stochastic growth to rapidly and economically build dense dendritic arbors.Nature communications · 2025Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Maximally efficient prediction in the early fly visual system may support evasive flight maneuvers.PLoS computational biology · 2021Article
- Single-neuron dynamical effects of dendritic pruning implicated in aging and neurodegeneration: towards a measure of neuronal reserve.Scientific reports · 2021Article
- Localized inhibition in theeLife · 2020Article
- Spatially resolved dendritic integration: towards a functional classification of neurons.PeerJ · 2020Article
- Generation of Granule Cell Dendritic Morphologies by Estimating the Spatial Heterogeneity of Dendritic Branching.Frontiers in computational neuroscience · 2020Article
- Conserved neural circuit structure acrosseLife · 2017Article
- Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion.eLife · 2017Article
- Article
- A Novel Form of Compensation in the Tg2576 Amyloid Mouse Model of Alzheimer's Disease.Frontiers in cellular neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Important brain functions need to be conserved throughout organisms of extremely varying sizes. Here we study the scaling properties of an essential component of computation in the brain: the single neuron. We compare morphology and signal propagation of a uniquely identifiable interneuron, the HS cell, in the blowfly (Calliphora) with its exact counterpart in the fruit fly (Drosophila) which is about four times smaller in each dimension. Anatomical features of the HS cell scale isometrically and minimise wiring costs but, by themselves, do not scale to preserve the electrotonic behaviour. However, the membrane properties are set to conserve dendritic as well as axonal delays and attenuation as well as dendritic integration of visual information. In conclusion, the electrotonic structure of a neuron, the HS cell in this case, is surprisingly stable over a wide range of morphological scales.
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