ArticlePloS one2013
Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.Nature communications · 2021Pooled it
- Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants.Journal of the American Heart Association · 2020Pooled it
- Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.International journal of epidemiology · 2016Pooled it
- Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.Cardiovascular diabetology · 2016Pooled it
- Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans.PloS one · 2016Pooled it
- Article
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- Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance.BMC medicine · 2023Article
- Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.Science advances · 2023Article
- Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes.Communications medicine · 2023Article
- Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.Nature communications · 2021Article
- Metabolic profiles of socio-economic position: a multi-cohort analysis.International journal of epidemiology · 2021Article
- Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Establishing reference intervals for triglyceride-containing lipoprotein subfraction metabolites measured using nuclear magnetic resonance spectroscopy in a UK population.Annals of clinical biochemistry · 2021Article
- Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults.European journal of preventive cardiology · 2020Article
- Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment.Neurology · 2020Article
- Axes of a revolution: challenges and promises of big data in healthcare.Nature medicine · 2020Review
- The effect of mid-life insulin resistance and type 2 diabetes on older-age cognitive state: the explanatory role of early-life advantage.Diabetologia · 2019Article
- Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study.Diabetes · 2019Article
- The Effect of Pre-Analytical Conditions on Blood Metabolomics in Epidemiological Studies.Metabolites · 2019Article
Corrections and comments
- Erratum issuedSwerdlow, Daniel I [added]; Langenberg, Claudia [added]
Authors and funding
47 authors.
Funding
Abstract
Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.