ArticlePloS one2013
A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-¹³C]-pyruvate.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026Article
- Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer.Magnetic resonance in medicine · 2026Article
- Design and chemical composition of a reference phantom forMagma (New York, N.Y.) · 2026Article
- Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024Review
- Model-constrained reconstruction accelerated with Fourier-based undersampling for hyperpolarized [1-Magnetic resonance in medicine · 2023Article
- A reproducible dynamic phantom for sequence testing in hyperpolarisedThe British journal of radiology · 2022Article
- Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.Medical physics · 2021Article
- Comparison of selective excitation and multi-echo chemical shift encoding for imaging of hyperpolarized [1-Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Slice profile effects on quantitative analysis of hyperpolarized pyruvate.NMR in biomedicine · 2020Article
- Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia.Molecular cancer therapeutics · 2019Article
- Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate.Magnetic resonance in medicine · 2019Article
- Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.Molecular imaging and biology · 2019Article
- HyperpolarizedNeoplasia (New York, N.Y.) · 2019Review
- Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents.Journal of visualized experiments : JoVE · 2016Article
- A novel perfused Bloch-McConnell simulator for analyzing the accuracy of dynamic hyperpolarized MRS.Medical physics · 2016Article
- Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.Cancer research · 2015Article
- High-throughput hyperpolarized (13)C metabolic investigations using a multi-channel acquisition system.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
- Feasibility of multianimal hyperpolarized (13) C MRS.Magnetic resonance in medicine · 2015Article
- Review
- The effect of exogenous substrate concentrations on true and apparent metabolism of hyperpolarized pyruvate in the isolated perfused lung.NMR in biomedicine · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In vivo real time spectroscopic imaging of hyperpolarized ¹³C labeled metabolites shows substantial promise for the assessment of physiological processes that were previously inaccessible. However, reliable and reproducible methods of measurement are necessary to maximize the effectiveness of imaging biomarkers that may one day guide personalized care for diseases such as cancer. Animal models of human disease serve as poor reference standards due to the complexity, heterogeneity, and transient nature of advancing disease. In this study, we describe the reproducible conversion of hyperpolarized [1-¹³C]-pyruvate to [1-¹³C]-lactate using a novel synthetic enzyme phantom system. The rate of reaction can be controlled and tuned to mimic normal or pathologic conditions of varying degree. Variations observed in the use of this phantom compare favorably against within-group variations observed in recent animal studies. This novel phantom system provides crucial capabilities as a reference standard for the optimization, comparison, and certification of quantitative imaging strategies for hyperpolarized tracers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.